蜂房哈夫尼亚菌外膜蛋白的免疫原性和保护特性
Immunogenic and protective properties of outer membrane proteins of Hafnia alvei.
作者信息
Witkowska D, Czarny A, Mulczyk M
机构信息
Laboratory of Medical Microbiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
出版信息
Arch Immunol Ther Exp (Warsz). 1990;38(5-6):387-93.
Outer membrane proteins (OMP) extracted from antigenically distinct or related strains of Hafnia alvei containing defined composition of major proteins proved to be immunogenic. Intraperitoneal immunization of mice with a single dose of such preparations protected the animals against homologous and heterologous Hafnia strains. The OMP preparations were also found to induce protection with varying intensity against Escherichia, Proteus, Shigella and Salmonella.
从具有明确主要蛋白质组成的不同抗原性或相关的蜂房哈夫尼亚菌菌株中提取的外膜蛋白（OMP）被证明具有免疫原性。用单剂量的此类制剂对小鼠进行腹腔免疫可保护动物免受同源和异源蜂房哈夫尼亚菌菌株的侵害。还发现OMP制剂对大肠杆菌、变形杆菌、志贺氏菌和沙门氏菌具有不同强度的诱导保护作用。
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