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发育异常痣(非典型痣)。

Dysplastic nevus (atypical nevus).

作者信息

Rezze Gisele Gargantini, Leon Alexandre, Duprat João

机构信息

Department of Cutaneous Oncology, AC Camargo Hospital, Sao Paulo, SP, Brazil.

出版信息

An Bras Dermatol. 2010 Nov-Dec;85(6):863-71. doi: 10.1590/s0365-05962010000600013.

Abstract

Atypical nevum (dysplastic) is considered an important factor associated with increased risk of developing cutaneous melanoma. It is believed that atypical nevi are precursor lesions of cutaneous melanoma. They may be present in patients with multiple melanocytic nevi (atypical nevus syndrome) or isolated and in small numbers in a non-familial context. The disease usually begins at puberty and predominates in young people. It has a predilection for sun-exposed areas, especially the trunk. The major challenge in relation to atypical nevi lies in the controversy of defining its nomenclature, clinical diagnosis, dermoscopic criteria, histopathological diagnosis and molecular aspects. This review aims at bringing knowledge, facilitating comprehension and clarifying doubts about atypical nevus.

摘要

非典型痣(发育异常痣)被认为是与皮肤黑色素瘤发病风险增加相关的重要因素。人们认为非典型痣是皮肤黑色素瘤的前驱病变。它们可能存在于患有多发性黑素细胞痣的患者(非典型痣综合征)中,也可能在非家族性背景下孤立且少量出现。该病通常始于青春期,在年轻人中更为常见。它好发于暴露于阳光的部位,尤其是躯干。与非典型痣相关的主要挑战在于其命名、临床诊断、皮肤镜标准、组织病理学诊断和分子方面定义的争议。本综述旨在提供有关非典型痣的知识,促进理解并澄清疑问。

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