Jitian Mihulecea Cristina-Raluca, Frățilă Simona, Rotaru Maria
Dermatology Clinic, Emergency Clinical County Hospital of Sibiu, 550245 Sibiu, Romania.
Doctoral Studies, 'Victor Babeș' University of Medicine and Pharmacy of Timișoara, 300041 Timișoara, Romania.
Exp Ther Med. 2021 Aug;22(2):854. doi: 10.3892/etm.2021.10286. Epub 2021 Jun 9.
Atypical (Clark) nevi are benign tumors that may be considered precursors of melanoma. Many studies acknowledge a linear progression from typical to atypical nevi that eventually transform into melanoma. It is often challenging to differentiate a Clark nevus from melanoma, especially in its early stages, due to their clinical, dermoscopic, and histological resemblance. Dermoscopy is a powerful tool in early melanoma diagnosis, but it is a subjective method of examination. Therefore, the use of dermoscopic algorithms and checklists can overcome this issue. In the case of a difficult diagnosis, since both dermoscopy and histopathological exam are subjective methods of examination, modern molecular biology techniques can be used to distinguish between benign and malignant tumors. This study aimed to test the accuracy of specific clinical and dermoscopic criteria in order to distinguish between benign and malignant tumors, with a secondary objective to provide an overview of the clinical and dermoscopic features of atypical nevi and melanoma. In the present study, dermoscopic algorithms did not necessarily help distinguish benign and malignant tumors but demonstrated that nevi and melanoma have similar characteristics.
非典型（克拉克）痣是良性肿瘤，可能被视为黑色素瘤的前体。许多研究承认从典型痣到非典型痣存在线性进展，最终会转变为黑色素瘤。由于克拉克痣与黑色素瘤在临床、皮肤镜和组织学上相似，尤其是在早期阶段，区分克拉克痣和黑色素瘤往往具有挑战性。皮肤镜检查是早期黑色素瘤诊断的有力工具，但它是一种主观的检查方法。因此，使用皮肤镜算法和检查表可以克服这个问题。在诊断困难的情况下，由于皮肤镜检查和组织病理学检查都是主观的检查方法，可以使用现代分子生物学技术来区分良性和恶性肿瘤。本研究旨在测试特定临床和皮肤镜标准区分良性和恶性肿瘤的准确性，其次要目标是概述非典型痣和黑色素瘤的临床和皮肤镜特征。在本研究中，皮肤镜算法不一定有助于区分良性和恶性肿瘤，但表明痣和黑色素瘤具有相似的特征。
