Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA,
Curr Infect Dis Rep. 2010 Jul;12(4):291-8. doi: 10.1007/s11908-010-0106-3.
Meningitis caused by Mycobacterium tuberculosis remains an important cause of morbidity and mortality worldwide, and presents particular challenges in terms of diagnosis and management. The nonspecific clinical presentation of tuberculous meningitis (TBM) has led researchers to develop newer molecular methods of making the diagnosis. Several of these methods have excellent sensitivity and specificity, although many are not yet available for clinical use. Successful treatment of TBM requires a combination of antimicrobial agents, with vigilance regarding the possibility of disease caused by resistant organisms. Adjunctive corticosteroids also have a role in treating this potentially devastating infection, as can neurosurgery. With proper therapy, morbidity and mortality can be minimized in patients with TBM.
结核性脑膜炎是由结核分枝杆菌引起的，它仍然是全世界发病率和死亡率的一个重要原因，在诊断和管理方面带来了特殊的挑战。结核性脑膜炎（TBM）的非特异性临床表现促使研究人员开发出更新的分子诊断方法。这些方法中的许多方法具有出色的灵敏度和特异性，尽管其中许多方法尚未用于临床。成功治疗 TBM 需要联合使用抗菌药物，并警惕可能由耐药菌引起的疾病。皮质类固醇激素也可以作为辅助治疗，神经外科手术也可以。通过适当的治疗，可以将 TBM 患者的发病率和死亡率降至最低。
