Sitarek K, Barański B
Department of Occupational Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland.
Pol J Occup Med. 1990;3(2):209-13.
An aqueous solution of trioxane was administered by gavage to female rats, 5 days per week for 7 weeks, at doses of 0.19, 0.58 and 1.16 g/kg/day. A significant increase in the mean duration of the oestrous cycle, mainly due to lengthening of the dioestrus, was only noted in the 6th and 7th week of treatment in females given per os trioxane at a dose of 1.16 g/kg. Three weeks after cessation of treatment, no alterations of oestrous cycle were observed in all groups. Since a dose-related decrease in body weight gain was observed in females given trioxane by gavage at doses of 0.19-1.16 g/kg and trioxane-induced behavioral changes were seen in the 1.16 g/kg group, it was concluded that exposure to trioxane did not affect the sexual cycle unless other overt signs of trioxane toxicity were induced.
将三聚甲醛的水溶液通过灌胃给予雌性大鼠，每周5天，持续7周，剂量分别为0.19、0.58和1.16克/千克/天。仅在以1.16克/千克的剂量经口给予三聚甲醛的雌性大鼠治疗的第6周和第7周，观察到发情周期的平均持续时间显著增加，主要是由于间情期延长。治疗停止三周后，所有组均未观察到发情周期的改变。由于在以0.19 - 1.16克/千克的剂量通过灌胃给予三聚甲醛的雌性大鼠中观察到体重增加呈剂量相关下降，并且在1.16克/千克组中出现了三聚甲醛诱导的行为变化，因此得出结论，除非诱导出三聚甲醛毒性的其他明显迹象，否则接触三聚甲醛不会影响性周期。
