Shao Hui, Weerasekare G Mahika, Stewart Russell J
Department of Bioengineering, University of Utah, 20 S. 2030 East, Room 506C, Salt Lake City, Utah 84112.
J Biomed Mater Res A. 2011 Apr;97(1):46-51. doi: 10.1002/jbm.a.33026. Epub 2011 Feb 9.
Periodate oxidation of carbohydrates with vicinal hydroxyl groups and aromatic ortho-dihydroxyphenyl groups has been employed extensively to initiate crosslinking or conjugation reactions in adhesive biomaterials. Periodate forms stable tridentate complexes with carbohydrates containing three appropriately configured hydroxyls, such as 1,2-O-isopropylidene-a-D-glucofuranose, that are not appreciably oxidized relative to carbohydrates with vicinal hydroxyls and ortho-dihydroxyphenyl groups. In the presence of 1,2-O-Isopropylidene-a-D-glucofuranose the rate of periodate oxidation of dihydroxy containing compounds is controlled by the rates of association and dissociation of the periodate-carbohydrate complex. By varying the ratio of 1,2-O-isopropylidene-a-D-glucofuranose to periodate the curing rate of adhesive complex coacervates was varied over a wide range.
具有邻位羟基的碳水化合物和芳族邻二羟基苯基的高碘酸盐氧化已被广泛用于引发粘性生物材料中的交联或共轭反应。高碘酸盐与含有三个构型适当的羟基的碳水化合物形成稳定的三齿配合物，例如1,2-O-异亚丙基-α-D-葡萄糖呋喃糖，相对于具有邻位羟基和邻二羟基苯基的碳水化合物，它们不会被明显氧化。在1,2-O-异亚丙基-α-D-葡萄糖呋喃糖存在下，含二羟基化合物的高碘酸盐氧化速率由高碘酸盐-碳水化合物配合物的缔合和解离速率控制。通过改变1,2-O-异亚丙基-α-D-葡萄糖呋喃糖与高碘酸盐的比例，粘性复合凝聚层的固化速率在很宽的范围内变化。
