Kramers M T, Catovsky D, Foa R
Br J Haematol. 1978 Sep;40(1):111-8. doi: 10.1111/j.1365-2141.1978.tb03644.x.
The distribution of two cell membrane enzymes, alkaline phosphatase and alkaline phosphodiesterase I has been studied in normal and leukaemic lymphocytes. No reduction in the level of activity of either enzyme was found in the chronic or acute B- and T-cell leukaemias. Alkaline phosphatase activity was elevated in the lymphocytes from T-CLL, cord blood and tonsils and the blast cells from Null-ALL. Alkaline phosphodiesterase was elevated in lymphocytes from cord blood and tonsils and the blast cells from Null-ALL. As findings in Null-ALL were based on only two cases, they need confirmation in a larger series. The significance of these results is discussed in relation to current theories of maturation and differentiation in the lymphoproliferative disorders.
已经对正常和白血病淋巴细胞中两种细胞膜酶——碱性磷酸酶和碱性磷酸二酯酶I的分布进行了研究。在慢性或急性B细胞和T细胞白血病中，未发现这两种酶的活性水平降低。在T细胞慢性淋巴细胞白血病、脐带血和扁桃体的淋巴细胞以及裸细胞急性淋巴细胞白血病的原始细胞中，碱性磷酸酶活性升高。在脐带血和扁桃体的淋巴细胞以及裸细胞急性淋巴细胞白血病的原始细胞中，碱性磷酸二酯酶升高。由于裸细胞急性淋巴细胞白血病的研究结果仅基于两例病例，因此需要在更大的病例系列中进行证实。结合淋巴细胞增殖性疾病中成熟和分化的当前理论，对这些结果的意义进行了讨论。
