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Time to rethink clinically important outcomes in platelet transfusion trials.

作者信息

Heddle Nancy M, Arnold Donald M, Webert Kathryn E

机构信息

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

出版信息

Transfusion. 2011 Feb;51(2):430-4. doi: 10.1111/j.1537-2995.2010.02982.x. Epub 2010 Dec 16.

DOI:10.1111/j.1537-2995.2010.02982.x
PMID:21309780
Abstract
摘要

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1
Time to rethink clinically important outcomes in platelet transfusion trials.是时候重新思考血小板输注试验中具有临床重要意义的结果了。
Transfusion. 2011 Feb;51(2):430-4. doi: 10.1111/j.1537-2995.2010.02982.x. Epub 2010 Dec 16.
2
The clinician as investigator: participating in clinical trials in the practice setting: Appendix 2: statistical concepts in study design and analysis.临床医生作为研究者:在实际临床环境中参与临床试验:附录2:研究设计与分析中的统计学概念
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The clinician as investigator: participating in clinical trials in the practice setting: Appendix 1: fundamentals of study design.临床医生作为研究者:在临床实践中参与临床试验:附录1:研究设计基础
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Methods for the analysis of bleeding outcomes in randomized trials of PLT transfusion triggers.血小板输注触发因素随机试验中出血结局的分析方法
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Background, rationale, and design of a clinical trial to assess the effects of platelet dose on bleeding risk in thrombocytopenic patients.一项评估血小板剂量对血小板减少症患者出血风险影响的临床试验的背景、理论依据和设计。
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[Indication for platelet transfusion in patients with haematological diseases: less is more].
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Clinical trials evaluating pathogen-reduced platelet products: methodologic issues and recommendations.评价病原体减少血小板产品的临床试验:方法学问题与建议。
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Prophylactic platelet transfusions versus no prophylaxis in hospitalized patients with thrombocytopenia: A systematic review with meta-analysis.住院血小板减少症患者预防性输注血小板与不进行预防的比较:一项系统评价与荟萃分析
Transfusion. 2022 Oct;62(10):2117-2136. doi: 10.1111/trf.17064. Epub 2022 Aug 20.
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Bleeding assessment and bleeding severity in thrombocytopenic patients undergoing invasive procedures.血小板减少症患者在接受侵入性操作时的出血评估及出血严重程度
Transfusion. 2020 Mar;60(3):637-649. doi: 10.1111/trf.15670. Epub 2020 Jan 31.
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The association between haemorrhage and markers of endothelial insufficiency and inflammation in patients with hypoproliferative thrombocytopenia: a cohort study.
低增生性血小板减少症患者出血与血管内皮功能不全和炎症标志物的相关性:一项队列研究。
Br J Haematol. 2020 Apr;189(1):171-181. doi: 10.1111/bjh.16291. Epub 2019 Nov 15.
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The identification of cases of major hemorrhage during hospitalization in patients with acute leukemia using routinely recorded healthcare data.利用常规记录的医疗保健数据识别急性白血病住院患者的大出血病例。
PLoS One. 2018 Aug 15;13(8):e0200655. doi: 10.1371/journal.pone.0200655. eCollection 2018.
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Rationale and design of platelet transfusions in haematopoietic stem cell transplantation: the PATH pilot study.造血干细胞移植中血小板输注的原理与设计:PATH试点研究
BMJ Open. 2016 Oct 24;6(10):e013483. doi: 10.1136/bmjopen-2016-013483.
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A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial.一项评估血小板输注产品临床效果的随机对照试验研究方案:病原体灭活评估与预测分析评分(PREPAReS)试验
BMJ Open. 2016 Jan 27;6(1):e010156. doi: 10.1136/bmjopen-2015-010156.