Semel Institute-Center for Community Health, University of California, Los Angeles, 10920 Wilshire Blvd., Suite 350, Los Angeles, CA 90024, USA.
Drug Alcohol Depend. 2011 Aug 1;117(1):45-9. doi: 10.1016/j.drugalcdep.2011.01.004. Epub 2011 Feb 9.
Dosage of methadone maintenance therapy (MMT) is an important factor influencing retention in methadone treatment. MMT clients in China received lower dosages of methadone compared with those provided in other countries. The objective of this study is to elucidate the reason for the low methadone dosage prescribed in MMT clinics in China.
Twenty-eight service providers were recruited from the MMT clinics in Zhejiang and Jiangxi Provinces, China. Qualitative in-depth interviews were conducted to ascertain the procedure for prescribing methadone in the MMT clinics.
The average dosage prescribed in the 28 clinics was 35 mg/person/day. Four major themes resulting in low dosage of methadone were identified: (1) the service providers fear the liability resulting from large doses of methadone in combination with other substances which might result in overdose fatalities, (2) lack of understanding of harm reduction which resulted in low acceptance of the long term maintenance treatment approach, (3) break-down in communication between clients and service providers about dosage adjustment, and (4) dosage reduction is perceived by most service providers as an effective way to treat the side-effects associated with MMT.
The findings of the study highlighted the necessity to formulate clear guidelines concerning individualized dosage management and to improve training among service providers' in MMT clinics in China.
美沙酮维持治疗(MMT)的剂量是影响美沙酮治疗保留率的一个重要因素。与其他国家相比,中国的 MMT 患者接受的美沙酮剂量较低。本研究旨在阐明中国 MMT 诊所开具的美沙酮剂量较低的原因。
从中国浙江和江西两省的 MMT 诊所招募了 28 名服务提供者。通过定性深入访谈,确定 MMT 诊所开具美沙酮的程序。
28 家诊所开出的平均剂量为 35 毫克/人/天。确定了导致美沙酮低剂量的四个主要主题:(1)服务提供者担心大剂量美沙酮与其他物质结合可能导致过量死亡的责任;(2)对减少伤害的理解不足,导致对长期维持治疗方法的接受程度较低;(3)患者与服务提供者之间关于剂量调整的沟通中断;(4)大多数服务提供者认为减少剂量是治疗与 MMT 相关的副作用的有效方法。
研究结果强调有必要制定有关个体化剂量管理的明确指南,并在中国 MMT 诊所提高服务提供者的培训。