Mizuno Y, Matsumaru A, Funatsu K, Kobayashi K, Ebihara Y, Ueno M, Tsuchiya M
Ichikawa General Hospital, Tokyo Dental College.
Bull Tokyo Dent Coll. 1990 May;31(2):129-36.
The number of lymphocytes (especially T-lymphocytes) in peripheral blood decreases with aging. The decline is most evident in the thymus. In this study, total AN in the thymocytes of aged mice clearly decreases from that of young mice. The quantity of thymic hormones secreted by thymic cells decreases with the organism's thymus involution with age. After demonstrating the decrease in total AN (primarily ATP) levels within the thymocytes of aged mice, we attempted to reattain the levels of younger thymocytes by the administration of various thymic hormones. Examination of DNA in the thymocytes of 4 and 58-week-old mice, using flowcytometry, showed no differences in content. However, it is significant that aged mouse thymocytes's energy level can be returned to those of young mice with the application of Th-5.
外周血中淋巴细胞（尤其是T淋巴细胞）的数量会随着衰老而减少。这种减少在胸腺中最为明显。在本研究中，老年小鼠胸腺细胞中的总腺苷酸（AN）明显低于年轻小鼠。随着机体胸腺随年龄退化，胸腺细胞分泌的胸腺激素量会减少。在证实老年小鼠胸腺细胞内总AN（主要是ATP）水平降低后，我们试图通过给予各种胸腺激素来恢复年轻胸腺细胞的水平。使用流式细胞术检测4周龄和58周龄小鼠胸腺细胞中的DNA，结果显示含量没有差异。然而，重要的是，应用Th-5可使老年小鼠胸腺细胞的能量水平恢复到年轻小鼠的水平。
