Jonderko G, Lachowicz K, Kita I, Kita K, Knapek R, Kotulska A
IV Katedry i Kliniki Chorób Wewnetrznych Sl. AM Kierownik.
Med Pr. 1990;41(4):216-24.
The fungicide for corn PF-70 contains 21% of sulphur, 8.4% of mancozeb, and 0.6% of triadimefon . The aim of the study was to determine the effect of the fungicide on the gastric mucosa electrolyte barrier in rats. Mucosa lesion is known to be one of the risk factors of chronic peptic ulcer disease. The experiments were carried out on 80 rats of Wistar strain. The animals were divided into 5 groups--males and females, separately. The fungicide was given for 13 weeks, at the following doses: 100, 400, 1600, and 6400 mg of active substance per 1 kg of fodder. The gastric mucosa electrolyte barrier was examined by determining the transmural electric potential differences (PD) in mucosa before and after treatment with 150 mmlo of hydrochloric acid and 40 mmol of acetylsalicylic acid solutions. No changes in general condition of the animals were observed. An increase in fodder consumption was observed in males receiving the fungicide at doses of 1600 and 6400 mg per 1 kg of fodder. Females exhibited a decrease in body mass after intoxication at concentration of 6400 mg/kg fodder. A decrease in PD was found in all groups intoxicated with the fungicide, irrespective of the animal sex.
玉米用杀菌剂PF - 70含有21%的硫、8.4%的代森锰锌和0.6%的三唑酮。本研究的目的是确定该杀菌剂对大鼠胃黏膜电解质屏障的影响。已知黏膜损伤是慢性消化性溃疡疾病的危险因素之一。实验用80只Wistar品系大鼠进行。动物被分为5组——雄性和雌性分开。杀菌剂给药13周，剂量如下：每1千克饲料中含100、400、1600和6400毫克活性物质。通过测定用150毫摩尔盐酸和40毫摩尔乙酰水杨酸溶液处理前后黏膜的跨壁电位差（PD）来检测胃黏膜电解质屏障。未观察到动物一般状况的变化。在每1千克饲料中接受1600毫克和6400毫克剂量杀菌剂的雄性大鼠中观察到饲料消耗量增加。在饲料浓度为6400毫克/千克时中毒后，雌性大鼠体重下降。在用杀菌剂中毒的所有组中均发现PD降低，与动物性别无关。
