儿童期起病癫痫的精神神经发育障碍。
Psychiatric and neurodevelopmental disorders in childhood-onset epilepsy.
机构信息
Department of Biology, Northern Illinois University, DeKalb, IL 60115, USA.
出版信息
Epilepsy Behav. 2011 Mar;20(3):550-5. doi: 10.1016/j.yebeh.2010.12.038. Epub 2011 Feb 18.
Childhood-onset epilepsy is associated with psychiatric and cognitive difficulties and with poor social outcomes in adulthood. In a prospective cohort of young people with epilepsy, we studied psychiatric and neurodevelopmental disorders and epilepsy-related characteristics, all factors that may influence long-term social outcomes. Five hundred one subjects, 159 with complicated (IQ <80 or brain lesion) and 342 with uncomplicated epilepsy, were included. Psychiatric disorders and neurodevelopmental disorders were more common in complicated epilepsy (P<0.005). In uncomplicated epilepsy, externalizing but not internalizing disorders were strongly associated with neurodevelopmental disorders. Internalizing disorders and neurodevelopmental disorders were associated with lack of 5-year remission. Type of epilepsy was not associated with neurodevelopmental disorders or psychiatric disorders. Various comorbid conditions in epilepsy cluster together and are modestly associated with imperfect seizure control. These need to be considered together in evaluating and managing young people with epilepsy and may help explain long-term social outcomes above and beyond poor seizure control.
儿童期起病的癫痫与精神和认知困难以及成年后社会结局不良有关。在一项对患有癫痫的年轻人的前瞻性队列研究中，我们研究了精神和神经发育障碍以及与癫痫相关的特征，这些都是可能影响长期社会结局的因素。共纳入 501 名受试者，其中 159 名患有复杂（智商<80 或脑损伤）癫痫，342 名患有单纯性癫痫。复杂癫痫中更常见精神障碍和神经发育障碍（P<0.005）。在单纯性癫痫中，与神经发育障碍强烈相关的是外在而非内在障碍。内在障碍和神经发育障碍与 5 年无缓解相关。癫痫类型与神经发育障碍或精神障碍无关。癫痫中的各种合并症聚集在一起，与不完全控制癫痫发作有一定的相关性。在评估和管理患有癫痫的年轻人时，需要综合考虑这些因素，这可能有助于解释除了控制不佳之外的长期社会结局。
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