Neurological Surgery, P.C., Lake Success, NY 11042, USA.
Epilepsy Behav. 2010 Jan;17(1):70-4. doi: 10.1016/j.yebeh.2009.10.010. Epub 2009 Nov 12.
This retrospective study examined whether psychiatric conditions are directly related to epilepsy or, rather, are associated with underlying central nervous system (CNS) disorders linked to subsequent epilepsy. We examined data from a sample of older veterans (>65 years) receiving care from the Veterans Health Administration during fiscal year 2000. We compared individuals with new-onset epilepsy and individuals without epilepsy to examine the extent to which psychiatric disorders were associated with new-onset epilepsy; this analysis controlled for demographic and premorbid neurological risk factors previously associated with new-onset epilepsy. Premorbid psychiatric conditions occurred at higher rates in the epilepsy versus nonepilepsy groups, foremost including depression (17% vs 12%), anxiety (12% vs 8%), psychosis (12% vs 5%), and substance abuse (8% vs 4%). However, in the final model, only psychosis (OR=1.4, CI 1.2-1.6) was significantly associated with epilepsy when controlling for neurological disorders and psychiatric conditions (e.g., stroke, dementia, brain tumor, head injury).
这项回顾性研究旨在探讨精神疾病是否与癫痫直接相关，或者是否与随后发生癫痫相关的潜在中枢神经系统（CNS）疾病有关。我们研究了 2000 财年期间在退伍军人事务管理局接受治疗的老年退伍军人（>65 岁）样本中的数据。我们比较了新发癫痫患者和无癫痫患者，以检查精神障碍与新发癫痫之间的关联程度；这项分析控制了先前与新发癫痫相关的人口统计学和发病前神经风险因素。发病前的精神疾病在癫痫组中的发生率高于无癫痫组，主要包括抑郁（17%对 12%）、焦虑（12%对 8%）、精神病（12%对 5%）和物质滥用（8%对 4%）。然而，在最终模型中，仅精神病（OR=1.4，CI 1.2-1.6）在控制神经障碍和精神疾病（如中风、痴呆、脑肿瘤、头部损伤）后与癫痫显著相关。
