促肾上腺皮质激素（ACTH）和促黑素细胞激素（MSH）在主动和被动回避行为中的作用。

Involvement of ACTH and MSH in active and passive avoidance behavior.

作者信息

van Wimersma Greidanus T B, van Dijk A M, de Rotte A A, Goedemans J H, Croiset G, Thody A J

出版信息

Brain Res Bull. 1978 May-Jun;3(3):227-30. doi: 10.1016/0361-9230(78)90118-1.

Abstract

Intracerebroventricular injection of antiserum to alpha--MSH induces a weak reduction of passive avoidance latencies after administration prior to retention testing. Administration of antiserum to ACTH 1--24 induces a more marked effect in this respect, whereas injection of a combination of these antisera results in the strongest reduction of passive avoidance retention. No effect of this treatment is observed when these antisera are injected immediately after the learning trial. In active avoidance behavior a facilitation of extinction of the response is observed after intracerebroventricular administration of the antisera prior to each extinction session. This effect is comparable with the one observed in passive avoidance behavior. From these data it is suggested that ACTH and alpha-MSH play an important role in processes related to the retrieval of information stored in the brain.

摘要

在记忆保持测试前给予α-促黑素（α-MSH）抗血清进行脑室内注射，会使被动回避潜伏期出现轻微缩短。给予促肾上腺皮质激素（ACTH）1-24抗血清在这方面会产生更显著的效果，而注射这两种抗血清的组合会导致被动回避记忆的最大程度减退。当在学习试验后立即注射这些抗血清时，未观察到这种处理的效果。在主动回避行为中，在每次消退训练前进行脑室内注射抗血清后，观察到反应消退的促进作用。这种效应与在被动回避行为中观察到的效应相当。从这些数据表明，促肾上腺皮质激素（ACTH）和α-促黑素（α-MSH）在与大脑中存储信息的检索相关的过程中起重要作用。