van Wimersma Greidanus T
Peptides. 1982 Jan-Feb;3(1):7-11. doi: 10.1016/0196-9781(82)90133-4.
MSH/ACTH4-10 induces a dose dependent increase of latency scores during retention of a passive avoidance response, when injected SC prior to retention but not when administered immediately after the learning trial. Intracerebroventricular administration of anti-vasopressin serum immediately after the learning trial or 1 hr prior to retention induces marked deficits in passive avoidance behavior as indicated by low latencies during retention. SC injection of MSH/ACTH4-10 increased latency scores in animals which received anti-vasopressin serum prior to retention, but did not alter latencies in animals, which received anti-vasopressin serum after the learning trial. These results suggest that MSH/ACTH4-10 is involved in retrieval processes and is able to differentiate between the effects of vasopressin on memory consolidation and on retrieval.
促黑素/促肾上腺皮质激素4 - 10在被动回避反应保持期间，于保持前皮下注射时可诱导潜伏期分数呈剂量依赖性增加，但在学习试验后立即给药则无此作用。学习试验后立即或在保持前1小时脑室内注射抗血管加压素血清，会导致被动回避行为出现明显缺陷，表现为保持期间潜伏期较短。在保持前接受抗血管加压素血清的动物中，皮下注射促黑素/促肾上腺皮质激素4 - 10可增加潜伏期分数，但在学习试验后接受抗血管加压素血清的动物中，该注射并未改变潜伏期。这些结果表明，促黑素/促肾上腺皮质激素4 - 10参与了提取过程，并且能够区分血管加压素对记忆巩固和提取的影响。
