Mwandila Munanga, Waller Hayley, Stott Victoria, Mercer Philippa
Department of Surgery, Christchurch Hospital, Christchurch, New Zealand.
N Z Med J. 2010 Nov 5;123(1325):80-2.
Oncocytic neoplasms are most rarely found in the adrenal gland. They are usually benign and non-functioning. We present a case of a testosterone-secreting oncocytic adrenocortical carcinoma in a 19-year-old female who presented with acne, hirsutism and irregular menses. Clinical investigations revealed an elevated testosterone and DHEA-S and a 4×5 cm left adrenal mass. The tumour was successfully excised. The histology showed the tumour to be comprised of oncocytic cells with granular, eosinophilic cytoplasm, features consistent with an oncocytic carcinoma. This is the first case presented of a testosterone-secreting oncocytic adrenocortical carcinoma.
嗜酸性细胞瘤在肾上腺中极为罕见。它们通常是良性且无功能的。我们报告一例19岁女性分泌睾酮的嗜酸性肾上腺皮质癌病例，该患者表现为痤疮、多毛症和月经不规律。临床检查发现睾酮和硫酸脱氢表雄酮水平升高，左侧肾上腺有一个4×5厘米的肿块。肿瘤被成功切除。组织学检查显示肿瘤由具有颗粒状、嗜酸性细胞质的嗜酸性细胞组成，这些特征与嗜酸性癌一致。这是首例分泌睾酮的嗜酸性肾上腺皮质癌病例。
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