Department of Systems Biomedicine, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan.
Cell Mol Life Sci. 2011 Jun;68(11):1843-9. doi: 10.1007/s00018-011-0629-2. Epub 2011 Feb 12.
Myogenesis has been a leading model for elucidating the molecular mechanisms that underlie tissue differentiation and development since the discovery of MyoD. During myogenesis, the fate of myogenic precursor cells is first determined by Pax3/Pax7. This is followed by regulation of the myogenic differentiation program by muscle regulatory factors (Myf5, MyoD, Myog, and Mrf4) to form muscle tissues. Recent studies have uncovered a detailed myogenic program that involves the RP58 (Zfp238)-dependent regulatory network, which is critical for repressing the expression of inhibitor of DNA binding (Id) proteins. These novel findings contribute to a comprehensive understanding of the muscle differentiation transcriptional program.
肌发生一直是阐明组织分化和发育基础的分子机制的主要模型，自 MyoD 的发现以来更是如此。在肌发生过程中，肌原性前体细胞的命运首先由 Pax3/Pax7 决定。随后，肌肉调节因子（Myf5、MyoD、Myog 和 Mrf4）调节肌发生分化程序，形成肌肉组织。最近的研究揭示了一个详细的肌发生程序，涉及 RP58（Zfp238）依赖性调节网络，该网络对于抑制 DNA 结合抑制剂（Id）蛋白的表达至关重要。这些新发现有助于全面理解肌肉分化转录程序。
