分析 HIV 暴露血清阴性者和不同疾病进展的 HIV 感染者中的 CD4+CD25+Foxp3+ 调节性 T 细胞。
Analysis of CD4+CD25+Foxp3+ regulatory T cells in HIV-exposed seronegative persons and HIV-infected persons with different disease progressions.
机构信息
Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
出版信息
Viral Immunol. 2011 Feb;24(1):57-60. doi: 10.1089/vim.2010.0079.
Regulatory T cells (Tregs) are a subset of T cells that play an important role in the regulation of T-cell function. In a previous study, CD25 was used as a marker of Tregs; however, FoxP3 was recently discovered to be a valuable phenotype of Tregs. In this study, we compared the frequency of Tregs in HIV-1-infected long-term nonprogressors (LTNP), AIDS patients (AP), HIV-exposed seronegative (ES) persons, and healthy controls (HC), by using CD4+CD25+FoxP3+ as a marker of Tregs. The results showed that the frequency of Tregs in AP was significantly higher than in the LTNP, ES, and HC, which suggests that Tregs may play a role in disease progression. Another unique finding in this study is that we found a decrease of Tregs in ES.
调节性 T 细胞（Tregs）是 T 细胞的一个亚群，在调节 T 细胞功能方面发挥着重要作用。在之前的研究中，CD25 被用作 Tregs 的标志物；然而，最近发现 FoxP3 是 Tregs 的一个有价值的表型。在这项研究中，我们使用 CD4+CD25+FoxP3+作为 Tregs 的标志物，比较了 HIV-1 感染的长期非进展者（LTNP）、艾滋病患者（AP）、HIV 暴露阴性（ES）个体和健康对照者（HC）中 Tregs 的频率。结果表明，AP 中 Tregs 的频率明显高于 LTNP、ES 和 HC，这表明 Tregs 可能在疾病进展中发挥作用。本研究的另一个独特发现是，我们发现 ES 中 Tregs 的数量减少。
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