Kays S E, Crowell W A, Johnson M A
Department of Foods and Nutrition, University of Georgia, Athens.
Magnes Trace Elem. 1990;9(6):294-302.
Lipid peroxidation may play a role in the acute nephrotoxicity of gentamicin (GM). Copper (Cu) depletion is associated with reduced activity of certain antioxidant enzymes in tissues, and with kidney lesions and impaired renal function. This study, therefore, investigated the effect of Cu nutrition on GM nephrotoxicity. Weanling male Sprague-Dawley rats were fed Cu adequate or Cu depleted diets for 16 days, then injected intraperitoneally with GM (0-100 mg.kg body weight-1.day-1) for 8 days. GM, but not mild Cu depletion, induced lesions in the kidney and increased plasma urea and urinary excretion of n-acetyl-beta-glucosaminidase. Lower iron in Cu-depleted kidneys and normal Cu, Zn-superoxide dismutase may have prevented additional GM damage during mild Cu depletion.
脂质过氧化可能在庆大霉素（GM）的急性肾毒性中起作用。铜（Cu）缺乏与组织中某些抗氧化酶活性降低、肾损伤及肾功能受损有关。因此，本研究调查了铜营养对庆大霉素肾毒性的影响。将断乳雄性Sprague-Dawley大鼠喂以含铜充足或缺铜的饲料16天，然后腹腔注射庆大霉素（0 - 100毫克·千克体重⁻¹·天⁻¹），持续8天。庆大霉素而非轻度铜缺乏诱导了肾脏损伤，并增加了血浆尿素和N-乙酰-β-氨基葡萄糖苷酶的尿排泄。缺铜肾脏中铁含量较低以及正常的铜、锌超氧化物歧化酶可能在轻度铜缺乏期间预防了庆大霉素的额外损伤。
