Gratzek Colville J, Johnson M A
Department of Foods and Nutrition, University of Georgia, Athens.
Magnes Trace Elem. 1991;10(1):21-9.
The development of Cu deficiency after prior exposure for 8 days to normal and high Cu and to normal and high Fe was examined in weanling male Sprague-Dawley rats. After 28 days of Cu depletion, those with high rather than normal initial Cu stores had less elevation in heart and liver weight; higher hemoglobin and hematocrit (by 17%), Cu,Zn-superoxide dismutase activity in liver (44%), cytochrome c oxidase activity in liver (66%) and heart (19%), and Cu concentration in liver (76%) and heart (37%). In contrast, high initial stores of Fe did not alter Cu status during Cu deprivation. Thus, prior exposure to Cu, but not Fe, decreased the severity of Cu deficiency.
在断乳雄性斯普拉格-道利大鼠中，研究了先暴露于正常和高铜以及正常和高铁环境8天后铜缺乏的发展情况。在铜耗竭28天后，初始铜储备高而非正常的大鼠，其心脏和肝脏重量的升高幅度较小；血红蛋白和血细胞比容更高（高17%），肝脏中铜锌超氧化物歧化酶活性更高（高44%），肝脏中细胞色素c氧化酶活性更高（高66%），心脏中细胞色素c氧化酶活性更高（高19%），肝脏中铜浓度更高（高76%），心脏中铜浓度更高（高37%）。相比之下，高初始铁储备在铜缺乏期间并未改变铜状态。因此，先前暴露于铜而非铁，降低了铜缺乏的严重程度。
