硝呋太尔对阴道细菌的体外活性：它是否可能成为治疗细菌性阴道病的良好候选药物？
In vitro activity of nifuratel on vaginal bacteria: could it be a good candidate for the treatment of bacterial vaginosis?
机构信息
Unilabs SA, Laboratoire Central de Suisse Romande, Ch. des Perrières 2, C.P. 100, CH-1296 Coppet, Switzerland.
出版信息
Antimicrob Agents Chemother. 2011 May;55(5):2490-2. doi: 10.1128/AAC.01623-10. Epub 2011 Feb 14.
Abstract
Bacterial vaginosis is characterized by a shift of the physiological flora to a diverse spectrum of bacteria, where Gardnerella vaginalis and Atopobium vaginae are the most important markers. In this study, the antimicrobial activity of nifuratel against G. vaginalis, A. vaginae, and lactobacilli was compared with that of the two currently used antibiotics metronidazole and clindamycin. Results suggest that nifuratel has a better spectrum of activity, being highly active against G. vaginalis and A. vaginae without affecting lactobacilli.
摘要
细菌性阴道病的特征是生理菌群向多样化的细菌谱转变，其中阴道加德纳菌和阴道阿托波菌是最重要的标志物。在这项研究中，比较了硝呋太尔对阴道加德纳菌、阴道阿托波菌和乳杆菌的抗菌活性与两种目前使用的抗生素甲硝唑和克林霉素的抗菌活性。结果表明，硝呋太尔具有更好的活性谱，对阴道加德纳菌和阴道阿托波菌高度活跃，而不影响乳杆菌。
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