Jiangsu Provincial Center for Disease Control and Prevention, No. 172 Jiangsu Road, Nanjing, Jiangsu, 210009, China.
Cancer Causes Control. 2011 Apr;22(4):649-57. doi: 10.1007/s10552-011-9737-4. Epub 2011 Feb 15.
Although the association for esophageal cancer with tobacco smoking and alcohol drinking has been well established, the risk appears to be less strong in China. To provide more evidence on the effect of smoking and alcohol consumption with esophageal cancer in China, particularly among Chinese women, a population-based case-control study has been conducted in Jiangsu, China, from 2003 to 2007. A total of 1,520 cases and 3,879 controls were recruited. Unconditional multivariate logistic regression analysis was applied. Results showed that the odds ratio (OR) and confidence interval (CI) for ever smoking and alcohol drinking were 1.57 (95% CI: 1.34-1.83) and 1.50 (95% CI: 1.29-1.74). Dose-response relationships were observed with increased intensity and longer duration of smoking/drinking. Risk of smoking and alcohol drinking at the highest joint level was 7.32 (95% CI: 4.58-11.7), when compared to those never smoked and never drank alcohol. Stratifying by genders, smoking and alcohol drinking increased the risk among men with an OR of 1.74 (95% CI: 1.44-2.09) and 1.76 (95% CI: 1.48-2.09); however, neither smoking nor alcohol consumption showed a significant association among women. In conclusion, smoking and alcohol drinking were associated with esophageal cancer risk among Chinese men, but not among Chinese women.
尽管吸烟和饮酒与食管癌之间的关联已得到充分证实，但在中国，这种风险似乎较弱。为了提供更多关于吸烟和饮酒对中国食管癌影响的证据，特别是对中国女性的影响，一项基于人群的病例对照研究于 2003 年至 2007 年在中国江苏进行。共招募了 1520 例病例和 3879 例对照。采用非条件多变量逻辑回归分析。结果表明，吸烟和饮酒的比值比（OR）和置信区间（CI）分别为 1.57（95%CI：1.34-1.83）和 1.50（95%CI：1.29-1.74）。随着吸烟/饮酒强度和持续时间的增加，呈现出剂量反应关系。与从不吸烟和饮酒的人相比，同时吸烟和饮酒的最高联合水平的风险为 7.32（95%CI：4.58-11.7）。按性别分层，吸烟和饮酒使男性食管癌的风险增加，OR 分别为 1.74（95%CI：1.44-2.09）和 1.76（95%CI：1.48-2.09）；然而，女性中吸烟或饮酒与食管癌均无显著关联。总之，吸烟和饮酒与中国男性食管癌风险相关，但与中国女性无关。
