Efficacy of candicidin in benign prostatic hypertrophy.

Forty-three patients with benign prostatic hypertrophy with marked urinary distress, which I believed warranted surgical treatment, were selected from private practice. These patients were treated with long-term conservative therapy to determine the efficacy of candicidin for this condition. Patients receiving candicidin orally 300 mg. per day showed improved subjective symptoms in 89.3 per cent of cases compared to 18.2 per cent for patients treated by placebos. Residual urine was decreased in 85.7 per cent and flow rate was improved in more than 89 per cent of the cases. More than one third of the patients treated with candicidin showed improvement in prostate size compared to none for patients treated with placebos. Occasional gastric upset was the only adverse effect attributed to candicidin, which appears to be a safe and efficacious agent.