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Candicidin treatment of prostatism: a prospective double-blind placebo-controlled study.

作者信息

Jensen K M, Madsen P O

出版信息

Urol Res. 1983;11(1):7-10. doi: 10.1007/BF00272701.

DOI:10.1007/BF00272701
PMID:6190290
Abstract

The polyene macrolide candicidin was investigated in the treatment of benign prostatic hyperplasia (BPH). Forty-one unselected patients with BPH and prostatism were admitted to a prospective, double-blind placebo-controlled clinical trial. Patients treated with 270 mg candicidin daily for 6 months had a significant decrease in residual urine and a significant increase in maximum flow rate after correction for differences in corresponding bladder volume. Symptoms improved significantly in both the candicidin and the placebo group but no differences in improvement were found between the two groups. The mechanism of the drug's effect is unknown and positive results are much less pronounced than those obtained with surgery. Candicidin appears valuable in the treatment of BPH patients who are a poor surgical risk.

摘要

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本文引用的文献

1
Efficacy of candicidin in benign prostatic hypertrophy.坎地沙坦在良性前列腺增生中的疗效。
Urology. 1974 Jul;4(1):80-4. doi: 10.1016/0090-4295(74)90113-7.
2
Micturition in the normal male.
Acta Chir Scand. 1958 Mar 8;114(3):197-210.
3
Normal peak urinary flow rates obtained from small voided volumes can provide a reliable assessment of bladder function.从小便尿量获得的正常尿流率峰值可对膀胱功能进行可靠评估。
J Urol. 1982 Mar;127(3):484-8. doi: 10.1016/s0022-5347(17)53877-x.
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Effects of cimetidine, progesterone, cannitracin and tolazoline on the weight and DNA content of the testosterone-induced hyperplastic prostate of the rat.西咪替丁、孕酮、杆菌肽锌和妥拉唑啉对睾酮诱导的大鼠前列腺增生的重量和DNA含量的影响。
Urol Res. 1988;16(5):363-6. doi: 10.1007/BF00256043.
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Benign prostatic hyperplasia and its treatment.良性前列腺增生及其治疗
J Gen Intern Med. 1990 Mar-Apr;5(2):153-65. doi: 10.1007/BF02600518.
4
Symptomatic treatment of benign prostatic obstruction with nicergoline: a placebo controlled clinical study and urodynamic evaluation.
Urol Res. 1982;10(3):131-4. doi: 10.1007/BF00255955.
5
[Candicidin treatment of benign hypertrophy of the prostate].[杀念菌素治疗前列腺良性增生]
Ugeskr Laeger. 1982 Jan 4;144(1):26-7.
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Accuracy in preoperative estimation of prostatic size. A comparative evaluation of rectal palpation, intravenous pyelography, urethral closure pressure profile recording and cystourethroscopy.
Scand J Urol Nephrol. 1981;15(1):45-51. doi: 10.3109/00365598109181212.
7
Evaluation of the role of injection therapy for benign prostatic hypertrophy.评估注射疗法在良性前列腺增生治疗中的作用。
Br J Urol. 1980 Jun;52(3):204-7. doi: 10.1111/j.1464-410x.1980.tb02960.x.
8
Uroflowmetry before and after prostatectomy.前列腺切除术前和术后的尿流率测定
South Med J. 1967 Sep;60(9):948-52. doi: 10.1097/00007611-196709000-00008.
9
The hypocholesterolemic activity of orally administered polyene macrolides.口服多烯大环内酯类药物的降胆固醇活性。
Proc Natl Acad Sci U S A. 1968 Sep;61(1):36-41. doi: 10.1073/pnas.61.1.36.
10
Antimycotics in hypertrophy of the prostate.抗真菌药与前列腺增生
Urol Int. 1970;25(2):196-200. doi: 10.1159/000279672.