Abe H
Ohu University Graduate School of Dentistry.
Ou Daigaku Shigakushi. 1990 Nov;17(3):372-94.
This study was carried out to clarify the clinico-pathological conditions of dysplasia, early carcinoma and invasive carcinoma (the invasion 5mm deep) in oral cavity. 57 cases (61 lesions), Which were resected by surgery alone, and diagnosed histologically as dysplasia, early invasive carcinoma and invasive carcinoma (the invasion 5mm deep), were used. All lesions were serially sectioned, and the relationship between clinical and histological appearances were examined. Further, a disease map was made in order to examine the distribution of carcinoma. Age of patients with an early carcinoma showed a wide distribution. Sex were 33 males and 24 females. Twenty-two cases of dysplasia showed white, red, red and white patch, and papillary outgrowth. Twenty-three cases of early invasive carcinoma showed same appearance as those of dysplasia. Sixteen cases of 5mm depth invasive carcinoma showed white, red, white and red patch, and granular and ulcerous appearance. In red lesions, so-called atypical vessels were seen. Atypical vessels were recognized as punctation. The punctation in area of dysplasia and carcinoma in situ were regular in shape. On the other hand, the punctation in 5mm deep invasive carcinoma became irregular in size and orientation. There was no correlation between the size and level of invasion. Fixed survival was 95.5% in early invasive carcinoma, 92.9% in 5mm deep invasive carcinoma. There were two types of distribution patterns of early invasive and 3mm deep invasive carcinoma; multi-centric and mono-centric pattern. All of 5mm deep invasive carcinoma showed mono-centric pattern, but the outline of carcinomatous area was more complicated in shape.
本研究旨在阐明口腔发育异常、早期癌和浸润癌（浸润深度达5mm）的临床病理情况。选取了57例（61个病灶）仅接受手术切除且经组织学诊断为发育异常、早期浸润癌和浸润癌（浸润深度达5mm）的病例。所有病灶均进行连续切片，检查临床与组织学表现之间的关系。此外，绘制了疾病分布图以研究癌的分布情况。早期癌患者的年龄分布较广。性别方面，男性33例，女性24例。22例发育异常表现为白色、红色、红白相间斑块及乳头状增生。23例早期浸润癌表现与发育异常相同。16例浸润深度达5mm的浸润癌表现为白色、红色、红白相间斑块及颗粒状和溃疡状外观。在红色病灶中可见所谓的非典型血管。非典型血管表现为点状。发育异常和原位癌区域的点状在形状上规则。另一方面，浸润深度达5mm的浸润癌中的点状在大小和方向上变得不规则。大小与浸润深度之间无相关性。早期浸润癌的固定生存率为95.5%，浸润深度达5mm的浸润癌为92.9%。早期浸润癌和浸润深度达3mm的浸润癌有两种分布模式：多中心和单中心模式。所有浸润深度达5mm的浸润癌均表现为单中心模式，但癌灶区域的轮廓形状更复杂。
