Glasgow Dental Hospital and School, University of Glasgow, Glasgow, UK.
J Clin Periodontol. 2011 Mar;38 Suppl 11:106-13. doi: 10.1111/j.1600-051X.2010.01669.x.
The aim of this paper is to provide a narrative review of the aetiopathogeneis and treatments of rheumatoid arthritis (RA), focusing on aspects that may share commonality with periodontitis.
A myriad of cell types, cytokines and pathways have been investigated in both periodontitis and RA. Chronic inflammatory diseases, including RA, psoriatic arthritis, ankylosing spondylitis and periodontitis are likely to share pathogenic mechanisms of inflammation-mediated solid tissue destruction. The aetiopathogenesis of these diseases has been extensively researched over the last several decades and advances in understanding have revolutionized arthritis therapeutics.
The rational, targeted inhibition of mediators in RA has provided clinically useful therapeutics and shed light on mechanisms underpinning disease pathogenesis. RA should be considered a prototypic disease revealing how understanding disease pathogenesis may transform therapeutic options and patient outcomes.
本文旨在对类风湿关节炎（RA）的病因和治疗进行叙述性综述，重点关注可能与牙周炎共有的方面。
在牙周炎和 RA 中，已经研究了无数的细胞类型、细胞因子和途径。包括 RA、银屑病关节炎、强直性脊柱炎和牙周炎在内的慢性炎症性疾病可能具有炎症介导的实体组织破坏的共同发病机制。过去几十年中，这些疾病的病因发病机制已经得到了广泛研究，对关节炎治疗学的理解也取得了重大进展。
RA 中介质的合理、靶向抑制为临床提供了有用的治疗方法，并阐明了疾病发病机制的相关机制。RA 应被视为一种典型疾病，揭示了对疾病发病机制的理解如何改变治疗选择和患者预后。
