牙周疾病与干燥综合征的关联：一项系统综述与荟萃分析。
The association of periodontal diseases and Sjogren's syndrome: A systematic review and meta-analysis.
作者信息
Yang Bo, Pang Xuefei, Guan Jiazhong, Liu Xu, Li Xiting, Wang Yan, Chen Zhuofan, Cheng Bin
机构信息
Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Department of Infectious Disease, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
出版信息
Front Med (Lausanne). 2023 Jan 5;9:904638. doi: 10.3389/fmed.2022.904638. eCollection 2022.
BACKGROUND
The relationship between periodontal diseases and Sjogren's syndrome were found inconsistent in current studies. Our objective is to clarify the relationship between periodontal diseases and Sjogren's syndrome.
METHODS
A systematic review was performed and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Electronic databases (EMBASE, PubMed, Web of Science, and Cochrane Library, from inceptions until 24 November 2021) were searched. The Newcastle-Ottawa Scale (NOS) and Agency for Healthcare Research and Quality (AHRQ) were applied to evaluate the quality of studies. Quality assessment of the certainty of evidence was performed based on the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines. When the output is the ratio, Odds ratio (OR) of periodontal diseases with Sjogren's syndrome were calculated. When the output is the mean, weighted mean difference (WMD) of periodontal diseases with Sjogren's syndrome was calculated. We conducted meta-analysis and estimated the pool sensitivity. Begg's test was used to test the possibility of publication bias. We also carried out meta-regression to clarify the source of heterogeneity (I2 > 50%). Finally, we performed a trial sequential analysis (TSA) to identify the false positive or false negative outcomes that might occur during repeated updates.
RESULTS
21 studies were included in this systematic review, with a total of 11435 subjects. Meta-analysis of 5 studies showed that there is a positive correlation between periodontitis and Sjogren's syndrome (OR = 2.12, 95% CI = 1.43-3.17; 5 studies, 6927 participants; low certainty of evidence). Meta-analysis of 16 studies showed that the periodontal condition of patients with Sjogren's syndrome was worse compared with the control group, and the scores of clinical periodontal parameters were relatively high.
CONCLUSION
Sjogren's syndrome patients seem to be more likely to be diagnosed with periodontal diseases. However, our results should be interpreted with caution considering the high heterogeneity.
SYSTEMATIC REVIEW REGISTRATION
[https://www.crd.york.ac.uk/prospero/], identifier [CRD42021261322].
背景
目前的研究发现牙周疾病与干燥综合征之间的关系并不一致。我们的目的是阐明牙周疾病与干燥综合征之间的关系。
方法
根据系统评价与荟萃分析的首选报告项目（PRISMA）进行系统评价并报告。检索了电子数据库（EMBASE、PubMed、Web of Science和Cochrane图书馆，从创刊至2021年11月24日）。应用纽卡斯尔-渥太华量表（NOS）和医疗保健研究与质量机构（AHRQ）评估研究质量。基于推荐分级评估、制定和评价（GRADE）指南对证据的确定性进行质量评估。当结果为比值时，计算牙周疾病与干燥综合征的比值比（OR）。当结果为均值时，计算牙周疾病与干燥综合征的加权均值差（WMD）。我们进行了荟萃分析并估计了合并敏感性。使用Begg检验来检验发表偏倚的可能性。我们还进行了荟萃回归以阐明异质性来源（I2>50%）。最后，我们进行了试验序贯分析（TSA）以识别在重复更新过程中可能出现的假阳性或假阴性结果。
结果
本系统评价纳入了21项研究，共11435名受试者。对5项研究的荟萃分析表明，牙周炎与干燥综合征之间存在正相关（OR = 2.12，95%CI = 1.43 - 3.17；5项研究，6927名参与者；证据确定性低）。对16项研究的荟萃分析表明，与对照组相比，干燥综合征患者的牙周状况更差，临床牙周参数得分相对较高。
结论
干燥综合征患者似乎更有可能被诊断为牙周疾病。然而，考虑到高度异质性，我们的结果应谨慎解释。
系统评价注册
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