Sugiyama O, Watanabe S, Tanaka K, Toya M, Igarashi S, Watanabe K, Tsuji K, Kumagai Y
Toxicology Research Laboratories, Chugai Pharmaceutical Co., Ltd., Nagano, Japan.
J Toxicol Sci. 1990 Nov;15 Suppl 3:91-107. doi: 10.2131/jts.15.supplementiii_91.
A perinatal and postnatal study was performed in rats by intraperitoneal administration of cefpirome sulfate (CPR) at dose levels of 0 (control), 200, 400 and 800 mg/kg/day to dams from day 17 of pregnancy to day 21 after delivery. Twenty one or twenty two dams in each group were allowed to deliver for the postnatal examination of their offsprings. No animal died. Loose feces were observed in the 800 mg/kg/day group. Body weight gain of the dams was retarded in the 800 mg/kg/day group in the early stage of treatment. Food intake was reduced simultaneously in the 200, 400 and 800 mg/kg/day groups. Autopsy revealed the enlargement of caecum in the 800 mg/kg/day. The adrenal weight was increased in the 400 and 800 mg/kg/day groups, and the kidney weight was increased in the 800 mg/kg/day group. The body weight of pups at birth in the 800 mg/kg/day group was slightly lower than that in the control group. The body weight of male pups in the 800 mg/kg/day group decreased transiently during rearing period. However, CPR had no adverse effects on the postnatal development such as viability, differentiation, emotionality, learning ability or reproductive performance. The results suggest that the non-effective dose level of CPR is lower than 200 mg/kg/day for general toxicity, 800 mg/kg/day for reproductive ability in maternal animals and 400 mg/kg/day in offsprings respectively.
通过对妊娠第17天至产后第21天的母鼠腹腔注射硫酸头孢匹罗（CPR），剂量分别为0（对照）、200、400和800mg/kg/天，进行了一项围产期和产后研究。每组21或22只母鼠分娩后对其后代进行产后检查。无动物死亡。在800mg/kg/天组观察到稀便。在治疗早期，800mg/kg/天组母鼠的体重增加受到抑制。200、400和800mg/kg/天组的食物摄入量同时减少。尸检显示800mg/kg/天组盲肠增大。400和800mg/kg/天组肾上腺重量增加，800mg/kg/天组肾脏重量增加。800mg/kg/天组出生时幼崽的体重略低于对照组。800mg/kg/天组雄性幼崽在饲养期间体重短暂下降。然而，CPR对产后发育如活力、分化、情绪、学习能力或生殖性能没有不良影响。结果表明，CPR的无效应剂量水平分别为一般毒性低于200mg/kg/天，对母动物生殖能力低于800mg/kg/天，对后代低于400mg/kg/天。
