线粒体转录：它是如何终止的？
Mitochondrial transcription: how does it end?
作者信息
Byrnes James, Garcia-Diaz Miguel
机构信息
Department of Pharmacology, Stony Brook University, NY, USA.
出版信息
Transcription. 2011 Jan-Feb;2(1):32-6. doi: 10.4161/trns.2.1.14006.
Abstract
The structure of the mitochondrial transcription termination factor (MTERF1) provides novel insight into the mechanism of binding, recognition of the termination sequence and the conformational changes involved in mediating termination. Besides its functional implications, this structure provides a framework to understand the consequences of numerous diseases associated with mitochondrial DNA mutations.
摘要
线粒体转录终止因子（MTERF1）的结构为其结合机制、终止序列识别以及介导终止过程中涉及的构象变化提供了全新的见解。除了其功能意义外，该结构还为理解与线粒体DNA突变相关的众多疾病的后果提供了一个框架。
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