Agusti-Mejias A, Sabater V, Messeguer F, García R, Ballester R, Marín S, Lloret A, Alegre V
Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, Spain.
Actas Dermosifiliogr. 2011 Jul-Aug;102(6):456-62. doi: 10.1016/j.ad.2010.09.010. Epub 2011 Feb 16.
Inflammatory myxohyaline tumor of the distal extremities is an extremely rare low-grade sarcoma with a tendency to produce local recurrence after surgical excision, but with a low metastatic potential. We present the case of a 49-year-old woman with a slow-growing asymptomatic tumor on the right pretibial region that was initially considered to be a lipoma. Histopathology revealed the presence of a polymorphic inflammatory infiltrate within a myxoid and hyaline matrix. Interspersed between the inflammatory cells were 3 different populations of neoplastic cells: atypical spindle-shaped cells; bizarre epithelioid cells, some of which were multinucleated and resembled the virocytes or Reed-Sternberg cells; and cells with abundant, vacuolated cytoplasm, similar to lipoblasts. These clinical-pathologic findings led to a diagnosis of inflammatory myxohyaline tumor of the distal extremities. Although the tumor was excised with wide surgical margins, local recurrence developed after 3 months and was treated with re-excision and radiotherapy.
肢体远端炎性黏液透明样肿瘤是一种极其罕见的低级别肉瘤，手术切除后有局部复发倾向，但转移潜能较低。我们报告一例49岁女性，其右胫骨前区有一个生长缓慢的无症状肿瘤，最初被认为是脂肪瘤。组织病理学显示在黏液样和透明样基质内存在多形性炎性浸润。炎性细胞之间散在分布着3种不同类型的肿瘤细胞：非典型梭形细胞；怪异的上皮样细胞，其中一些为多核，类似病毒细胞或里德-斯腾伯格细胞；以及细胞质丰富且有空泡的细胞，类似于脂肪母细胞。这些临床病理表现导致诊断为肢体远端炎性黏液透明样肿瘤。尽管肿瘤以较宽的手术切缘切除，但3个月后出现局部复发，随后进行了再次切除和放射治疗。
