Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States.
Curr Opin Genet Dev. 2011 Apr;21(2):154-9. doi: 10.1016/j.gde.2011.01.016. Epub 2011 Feb 15.
Memory T lymphocytes are distinct from antigen-inexperienced naïve T cells in that memory T cells can respond more rapidly when they re-encounter a pathogen. Work over the past decade has begun to define the epigenetic underpinnings of the transcriptional component of the memory T cell response. An emerging theme is the persistence of an active chromatin signature at relevant gene loci in resting memory T cells, even when those genes are transcriptionally inactive. This gives strength to the concept of gene poising, and has shown that memory T lymphocytes are an ideal model in which to further define various mechanisms of epigenetic poising.
记忆 T 淋巴细胞与无抗原经验的初始 T 细胞不同，因为记忆 T 细胞在再次遇到病原体时可以更快地做出反应。过去十年的研究已经开始定义记忆 T 细胞反应的转录成分的表观遗传基础。一个新兴的主题是，在静止的记忆 T 细胞中，相关基因座的染色质特征仍然保持活跃，即使这些基因的转录是不活跃的。这增强了基因 poised 的概念，并表明记忆 T 淋巴细胞是进一步定义各种表观遗传 poised 机制的理想模型。
