Gorsky Meir, Epstein Joel B
Department of Oral Pathology and Oral Medicine, the Maurice and Gabriella Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Apr;111(4):461-4. doi: 10.1016/j.tripleo.2010.11.007. Epub 2011 Feb 16.
Oral lichen planus (OLP) occurs in from 2% to 3% of the population and may have a risk of malignant transformation into squamous cell carcinoma (SCC). This risk is not necessarily associated with exposure to tobacco and alcohol. An increased awareness of a possible role of human papilloma virus (HPV) and SCC led us to review a possible association between this virus infection and malignant transformation of OLP. The possible linkage between HPV and the risk of transformation of OLP to malignancy is discussed. Furthermore, management of OLP using immunosuppressive drugs may be associated with enhanced viral replication and could theoretically affect the risk of malignant transformation. Implications for clinical care are discussed.
口腔扁平苔藓（OLP）在2%至3%的人群中出现，并且可能有恶变成为鳞状细胞癌（SCC）的风险。这种风险不一定与接触烟草和酒精有关。对人乳头瘤病毒（HPV）与SCC之间可能作用的认识增加，促使我们回顾这种病毒感染与OLP恶变之间的可能关联。本文讨论了HPV与OLP恶变风险之间的可能联系。此外，使用免疫抑制药物治疗OLP可能与病毒复制增强有关，并且理论上可能影响恶变风险。本文还讨论了对临床护理的影响。
