Leibovici J, Hoenig S, Horodniceanu E, Barot-Ciorbaru R
Department of Pathology, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
In Vivo. 1990 Sep-Oct;4(5):299-308.
Various Nocardial fractions have been shown to exert inhibitory effects against several experimental tumors, via a host response mechanism. With the aim of obtaining further information on the mechanism of action of these immunomodulators, we examined in the present study the local cellular host response induced by intratumoral administration of one of these fractions, the Nocardia-delipidated cell mitogen (NDCM), at the site of the tumor (Lewis lung carcinoma-3LL). The tumor itself was found to provoke a scanty cellular infiltration surrounding the tumor mass, mainly composed of lymphocytes. The site of the tumor in NDCM-treated mice was surrounded by a very thick rim of inflammatory cells, consisting of macrophages and lymphocytes. Although recognized decades ago, the existence of tumor infiltrating leukocytes still constitutes a puzzle. The composition and significance of these host cells, in both non-treated and treated tumors has not yet been elucidated. Since lymphocytes were also found around non-treated tumors and they apparently did not prevent tumor development, it is possible that macrophages play a more important role in the NDCM-elicited host defense against the Lewis lung carcinoma.
多种诺卡氏菌组分已被证明可通过宿主反应机制对多种实验性肿瘤发挥抑制作用。为了进一步了解这些免疫调节剂的作用机制，我们在本研究中检测了在肿瘤（Lewis肺癌-3LL）部位瘤内注射其中一种组分——诺卡氏菌脱脂细胞促分裂原（NDCM）所诱导的局部细胞宿主反应。发现肿瘤本身在肿瘤块周围引发了少量细胞浸润，主要由淋巴细胞组成。在接受NDCM治疗的小鼠中，肿瘤部位被一层非常厚的炎症细胞边缘所包围，这些炎症细胞由巨噬细胞和淋巴细胞组成。尽管几十年前就已认识到肿瘤浸润白细胞的存在，但它仍然是一个谜。这些宿主细胞在未治疗和治疗后的肿瘤中的组成和意义尚未阐明。由于在未治疗的肿瘤周围也发现了淋巴细胞，而且它们显然并未阻止肿瘤发展，因此巨噬细胞在NDCM引发的针对Lewis肺癌的宿主防御中可能发挥更重要的作用。
