钠钾ATP酶是激素哇巴因的假定膜受体。
Na,K-ATPase is the putative membrane receptor of hormone ouabain.
作者信息
Larre Isabel, Cereijido Marcelino
机构信息
Department of Physiology, Biophysics and Neurosciences; Center for Research & Advanced Studies (CINVESTAV); Mexico DF, Mexico.
出版信息
Commun Integr Biol. 2010 Nov;3(6):625-8. doi: 10.4161/cib.3.6.13498. Epub 2010 Nov 1.
Abstract
At 10 nM, ouabain elicits changes in cell contacts, which are independent and usually in opposite direction to effects occurring at µM levels, suggesting that these depend on entirely different mechanisms.1 However, this does not discard the possibility that in both instances ouabain would act on the same receptor. We demonstrate that such is the case by comparing the response of wild and ouabain-resistant MDCK cells on a very special type of cell contact, the tight junction (TJ).
摘要
在10纳摩尔浓度下，哇巴因会引起细胞接触的变化，这些变化是独立的，且通常与微摩尔浓度水平时产生的效应方向相反，这表明这些效应依赖于完全不同的机制。1然而，这并不排除在这两种情况下哇巴因都作用于同一受体的可能性。我们通过比较野生型和对哇巴因耐药的MDCK细胞在一种非常特殊的细胞接触类型——紧密连接（TJ）上的反应，证明了情况确实如此。
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