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一种用于群体大鼠软骨肉瘤原位模型闪烁成像和监测的“蛋白聚糖靶向策略”。

A"Proteoglycan targeting strategy" for the scintigraphic imaging and monitoring of the swarm rat chondrosarcoma orthotopic model.

作者信息

Peyrode Caroline, Gouin François, Vidal Aurélien, Auzeloux Philippe, Besse Sophie, Dauplat Marie-Mélanie, Askienazy Serge, Heymann Dominique, Chezal Jean-Michel, Redini Françoise, Miot-Noirault Elisabeth

机构信息

INSERM (UMR 990) Université d'Auvergne, rue Montalembert, BP 184, 63005 Clermont-Ferrand Cédex, France.

出版信息

Sarcoma. 2011;2011:691608. doi: 10.1155/2011/691608. Epub 2011 Feb 6.

DOI:10.1155/2011/691608
PMID:21331335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3038667/
Abstract

Our lab developed (99m)Tc-NTP 15-5 radiotracer as targeting proteoglycans (PGs) for the scintigraphic imaging of joint. This paper reports preclinical results of (99m)Tc-NTP 15-5 imaging of an orthotopic model of Swarm rat chondrosarcoma (SRC). (99m)Tc-NTP 15-5 imaging of SRC-bearing and sham-operated animals was performed and quantified at regular intervals after surgery and compared to bone scintigraphy and tumoural volume. Tumours were characterized by histology and PG assay. SRC exhibited a significant (99m)Tc-NTP 15-5 uptake at very early stage after implant (with tumour/muscle ratio of 1.61 ± 0.14), whereas no measurable tumour was evidenced. As tumour grew, mean tumour/muscle ratio was increased by 2.4, between the early and late stage of pathology. Bone scintigraphy failed to image chondrosarcoma, even at the later stage of study. (99m)Tc-NTP 15-5 imaging provided a suitable set of quantitative criteria for the in vivo characterization of chondrosarcoma behaviour in bone environment, useful for achieving a greater understanding of the pathology.

摘要

我们实验室研发了（99m）Tc-NTP 15-5放射性示踪剂，用于靶向蛋白聚糖（PGs），以进行关节闪烁成像。本文报道了对斯沃恩大鼠软骨肉瘤（SRC）原位模型进行（99m）Tc-NTP 15-5成像的临床前结果。对荷SRC和假手术动物进行了（99m）Tc-NTP 15-5成像，并在术后定期进行定量分析，同时与骨闪烁成像和肿瘤体积进行比较。通过组织学和PG检测对肿瘤进行特征分析。SRC在植入后非常早期就表现出显著的（99m）Tc-NTP 15-5摄取（肿瘤/肌肉比值为1.61±0.14），而此时尚无可测量的肿瘤。随着肿瘤生长，在病理早期和晚期之间，平均肿瘤/肌肉比值增加了2.4。即使在研究后期，骨闪烁成像也未能显示软骨肉瘤。（99m）Tc-NTP 15-5成像为在骨环境中对软骨肉瘤行为进行体内特征分析提供了一套合适的定量标准，有助于更深入地了解病理情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/6e121fa18426/SRCM2011-691608.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/73db30709b36/SRCM2011-691608.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/ed4339652c17/SRCM2011-691608.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/fc279b52c9ec/SRCM2011-691608.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/e9b7def481a1/SRCM2011-691608.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/daf779e45d34/SRCM2011-691608.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/a1b4f1673906/SRCM2011-691608.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/4daab9aba4f9/SRCM2011-691608.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/8a971342670e/SRCM2011-691608.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/6e121fa18426/SRCM2011-691608.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/73db30709b36/SRCM2011-691608.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/ed4339652c17/SRCM2011-691608.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/fc279b52c9ec/SRCM2011-691608.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/e9b7def481a1/SRCM2011-691608.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/daf779e45d34/SRCM2011-691608.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/a1b4f1673906/SRCM2011-691608.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/4daab9aba4f9/SRCM2011-691608.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/8a971342670e/SRCM2011-691608.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8d/3038667/6e121fa18426/SRCM2011-691608.009.jpg

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