Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Org Lett. 2011 Mar 18;13(6):1310-3. doi: 10.1021/ol103145g. Epub 2011 Feb 18.
A series of novel bifunctional phosphine-sulfonamide organic catalysts were designed and readily prepared from natural amino acids, and they were utilized to promote enantioselective aza-Morita-Baylis-Hillman (MBH) reactions. L-threonine-derived phosphine-sulfonamide 9b was found to be the most efficient catalyst, affording the desired aza-MBH adducts in high yields and with excellent enantioselectivities.
设计并简便制备了一系列新型双功能膦-磺酰胺有机催化剂，它们可用于促进对映选择性氮杂-Morita-Baylis-Hillman (MBH) 反应。从 L-苏氨酸衍生的膦-磺酰胺 9b 被发现是最有效的催化剂，以高收率和优异的对映选择性提供所需的氮杂-MBH 加合物。
