Department of Nephrology, The Second Xiangya Hospital, Nephrology Institute of Central South University, Changsha, 410011 Hunan, China.
Ren Fail. 2011;33(2):159-63. doi: 10.3109/0886022X.2011.552150.
The hallmark of IgA nephropathy (IgAN) is the mesangial deposits of polymeric IgA. However, the source of IgA1 and the mechanism of deposition of IgA1 in the mesangium remain unknown. To better understand its pathogenesis, we investigated the expression of CD19(+)CD5(+)B cells and IgA1-positive cells in the tonsils of IgAN patients. Immunofluorescence was used to visualize the locations of CD19(+)CD5(+)B cells and IgA1-positive cells in the tonsils. In this study, it was demonstrated that CD19(+)CD5(+)B cells are usually found in germinal centers and in the capsule covering the upper parts of the nodules of lymphoid tissue (cap of the nodule). The expression of IgA1-positive cells in tonsil tissue can be seen in the cap of the nodule and subepithelial tissue. There is a significant relationship between IgA1 and CD19(+)CD5(+)B cells. The level of CD19(+)CD5(+)B cells is positively correlated to the severity of renal pathological changes. These findings suggest that CD19(+)CD5(+)B cells in the tonsils could have an impact on the pathogenesis of IgAN.
IgA 肾病 (IgAN) 的特征是 IgA 聚合物在系膜沉积。然而，IgA1 的来源和 IgA1 在系膜中的沉积机制仍不清楚。为了更好地了解其发病机制，我们研究了 IgAN 患者扁桃体中 CD19(+)CD5(+)B 细胞和 IgA1 阳性细胞的表达。免疫荧光用于观察扁桃体中 CD19(+)CD5(+)B 细胞和 IgA1 阳性细胞的位置。本研究表明，CD19(+)CD5(+)B 细胞通常存在于生发中心和覆盖淋巴组织结节上部的包膜（结节帽）中。在扁桃体组织中可以看到 IgA1 阳性细胞在结节帽和上皮下组织中的表达。IgA1 与 CD19(+)CD5(+)B 细胞之间存在显著关系。CD19(+)CD5(+)B 细胞的水平与肾脏病理变化的严重程度呈正相关。这些发现表明扁桃体中的 CD19(+)CD5(+)B 细胞可能对 IgAN 的发病机制有影响。
