Jouhikainen T
Finnish Red Cross Blood Transfusion Service, Helsinki.
Blood Coagul Fibrinolysis. 1990 Dec;1(6):627-32.
The effects of oral anticoagulant therapy on the detection of lupus anticoagulant (LA) were studied in 110 patients with histories of thrombosis. LA was clearly positive in only two (2%) of the patients. Factor defects caused by warfarin therapy did not affect the kaolin clotting time (KCT) or recalcification time (RT) in mixing tests, but markedly affected the dilute Russell's viper venom time (DRVVT), resulting in 45 weak false-positive results. However, the problem was overcome in 93% of these cases by taking account of the basal prolongation of patients' DRVVT and the sensitivity of plasmas to dilution of the phospholipid reagent. A simple mathematical formula is suggested.
在110例有血栓形成病史的患者中，研究了口服抗凝治疗对狼疮抗凝物（LA）检测的影响。仅2例（2%）患者的LA呈明显阳性。华法林治疗引起的因子缺陷在混合试验中不影响高岭土凝血时间（KCT）或复钙时间（RT），但显著影响稀释蝰蛇毒时间（DRVVT），导致45例假阳性结果。然而，通过考虑患者DRVVT的基础延长以及血浆对磷脂试剂稀释的敏感性，93%的此类病例中的问题得到了解决。提出了一个简单的数学公式。
