Department of Dermatology, Royal Perth Hospital, Perth, Western Australia, Australia.
Australas J Dermatol. 2011 Feb;52(1):66-9. doi: 10.1111/j.1440-0960.2010.00676.x. Epub 2010 Aug 16.
An 87-year-old woman with eruptive keratoacanthomas complicating recent imiquimod therapy is presented. Lesions developed both at and distal to the treatment site. She responded well to 8 weeks of oral acitretin with resolution of most lesions and no recurrence at 6 months post treatment. A remaining lesion was excised and found to be a well-differentiated squamous cell carcinoma. Keratoacanthoma and squamous cell carcinoma should be considered in any patient developing rapidly growing keratotic nodules in association with recent imiquimod therapy. The aetiology and treatment of eruptive keratoacanthomas is briefly discussed.
一位 87 岁女性，近期接受咪喹莫特治疗后出现爆发性角化棘皮瘤，病变发生在治疗部位及其远端。她接受 8 周的口服阿维 A 治疗后，大部分皮损得到缓解，治疗后 6 个月无复发。遗留的一个皮损被切除，组织学检查为分化良好的鳞状细胞癌。任何近期接受咪喹莫特治疗后出现快速生长角化性结节的患者，均应考虑到角化棘皮瘤和鳞状细胞癌的可能。本文简要讨论了爆发性角化棘皮瘤的病因和治疗。
