The University of Pennsylvania, Philadelphia, PA, USA.
Int J Dermatol. 2011 Apr;50(4):470-7. doi: 10.1111/j.1365-4632.2010.04765.x. Epub 2011 Feb 20.
Hyperpigmentation disorders are common and diverse conditions that may require treatment for medical and/or cosmetic reasons. Hyperpigmented lesions can reduce patients' quality of life, self-perception, and social and vocational functioning. The most commonly used treatments for hyperpigmentation include topical agents, such as hydroquinone, retinoids and azelaic acid.
Current topical treatments have significant limitations; they often do not produce adequate results and may be limited by adverse effects, such as dermatitis. Soy and soy-based products have demonstrated a wide range of potential benefits for health and nutrition, including a range of dermatological effects.
Research from the last decade has identified multiple mechanisms by which soy-derived products may affect skin pigmentation, as well as photodamage and photoaging, overall skin health, and even the risk for and progression of skin cancer.
Preclinical evidence has demonstrated that soy-derived serine protease inhibitors affect skin pigmentation by inhibiting protease-activated receptor-2-mediated phagocytosis of melanosomes by keratinocytes.
Soy-based products containing these serine protease inhibitors may represent a new therapeutic option for dermatological treatment. Indeed, recent evidence from randomized clinical studies supports the safe and effective use of soy products for the treatment of hyperpigmentation.
色素沉着障碍是常见且多样化的病症，可能需要出于医疗和/或美容原因进行治疗。色素沉着病变会降低患者的生活质量、自我认知以及社交和职业功能。治疗色素沉着最常用的方法包括局部制剂，如对苯二酚、维甲酸和壬二酸。
目前的局部治疗方法存在显著的局限性；它们通常无法产生足够的效果，并且可能受到不良反应的限制，例如皮炎。大豆及其制品已被证明对健康和营养具有广泛的潜在益处，包括一系列皮肤科效应。
过去十年的研究已经确定了多种机制，通过这些机制，大豆衍生产品可能会影响皮肤色素沉着、光损伤和光老化、整体皮肤健康，甚至皮肤癌的风险和进展。
临床前证据表明，大豆衍生的丝氨酸蛋白酶抑制剂通过抑制蛋白酶激活受体-2 介导的角质形成细胞对黑素体的吞噬作用来影响皮肤色素沉着。
含有这些丝氨酸蛋白酶抑制剂的大豆产品可能代表一种新的治疗选择，用于皮肤科治疗。事实上，最近来自随机临床试验的证据支持安全有效地使用大豆制品治疗色素沉着。
