University of Pennsylvania, Philadelphia, PA, USA.
J Eur Acad Dermatol Venereol. 2011 Oct;25(10):1140-5. doi: 10.1111/j.1468-3083.2011.04130.x. Epub 2011 May 31.
Facial hyperpigmented disorders are a common complaint in the adult population of all races. First-line topical treatments are usually hydroquinone or topical retinoids, which can cause irritant reactions. The need for better tolerated, yet effective, skin lightening agents that could be utilized by a wider population has led to the investigation of several potential botanical/natural compounds. There are currently many topical cosmetic formulations claiming skin depigmenting effects. A few of the ingredients (e.g. soy) are supported not only by in vitro results but also by a body of controlled clinical efficacy studies; other ingredients, instead, are backed mostly by in vitro data and a few small uncontrolled clinical studies. In this review, we describe the most common natural ingredients used for skin depigmentation and their major published studies: soy, licorice extracts, kojic acid, arbutin, niacinamide, N-acetylglucosamine, COFFEEBERRY(™) and green tea.
面部色素沉着障碍是所有种族成年人中常见的主诉。一线局部治疗药物通常为氢醌或局部维 A 酸，可引起刺激性反应。为了寻找更好耐受、更有效的皮肤美白剂，使更广泛的人群能够使用，人们开始研究几种潜在的植物/天然化合物。目前有许多声称具有皮肤脱色效果的局部美容制剂。少数成分（如大豆）不仅有体外研究结果支持，还有大量对照临床试验结果支持；其他成分则主要有体外数据和少数小型非对照临床试验支持。在这篇综述中，我们描述了最常用于皮肤脱色的常见天然成分及其主要的已发表研究：大豆、甘草提取物、曲酸、熊果苷、烟酰胺、N-乙酰葡萄糖胺、COFFEEBERRY(™)和绿茶。
