Pôle pharmaceutique, University Hospital, Besançon, France.
Aliment Pharmacol Ther. 2011 Apr;33(8):940-5. doi: 10.1111/j.1365-2036.2011.04601.x. Epub 2011 Feb 20.
Low sunshine exposure might contribute to the pathogenesis of inflammatory bowel disease (IBD).
To assess the geographic distribution of IBD incidence in relation to sunshine exposure in France to test the hypothesis that higher sun exposure is associated with lower IBD risk.
Using the national health insurance database, incidence rates of Crohn's disease (CD) and ulcerative colitis (UC) were estimated for each of the 94 French administrative areas ('départements'), between 2000 and 2002. The surface UV radiation intensity was obtained by combining modelling and satellite data from Meteosat, the European meteorological satellite. Relationships between incidence rates and sun exposure were tested for significance by using a Poisson regression. We mapped smoothed relative risks (sRR) for CD and UC, using a Bayesian approach and adjusting for sun exposure, to search for geographical variations.
Areas with a smoothed RR of CD incidence significantly above 1 corresponded to areas with low sunshine exposure, whereas those with high or medium sunlight exposure had smoothed RRs either lower than 1 or not significantly different from 1. There was no association between sun exposure and UC incidence.
This geographic study suggests that low sunlight exposure is associated with an increased incidence of Crohn's disease. Further studies are needed to determine if this association is causal.
阳光照射不足可能会导致炎症性肠病（IBD）的发病机制。
评估法国阳光照射与炎症性肠病发病率之间的地理分布关系，以检验更高的阳光照射与更低的 IBD 风险相关的假设。
使用国家健康保险数据库，在 2000 年至 2002 年期间，对每个法国行政区域（départements）的克罗恩病（CD）和溃疡性结肠炎（UC）的发病率进行了估计。表面紫外线辐射强度通过将来自欧洲气象卫星 Meteosat 的建模和卫星数据进行组合来获得。使用泊松回归来测试发病率与阳光照射之间的关系是否具有统计学意义。我们使用贝叶斯方法对 CD 和 UC 的平滑相对风险（sRR）进行了映射，调整了阳光照射因素，以寻找地理差异。
CD 发病率的平滑 RR 显著高于 1 的区域与阳光照射不足的区域相对应，而阳光照射较高或中等的区域的平滑 RR 要么低于 1，要么与 1 无显著差异。阳光照射与 UC 发病率之间没有关联。
这项地理研究表明，低阳光照射与克罗恩病发病率的增加有关。需要进一步研究以确定这种关联是否具有因果关系。
