内毒素、血小板活化因子与动脉血栓形成
Endotoxin, PAF and arterial thrombosis.
作者信息
Bourgain R H, Andries R, Braquet P
机构信息
Laboratory of Physiology and Physiopathology, Free University of Brussels, Belgium.
出版信息
J Lipid Mediat. 1990;2 Suppl:S187-93.
Using an optoelectronic device, we demonstrated that endotoxin modulates platelet-activating factor (PAF)-induced arterial thrombosis in a mesenteric artery of the guinea-pig. Indeed, topical superfusion by PAF induces the generation of platelet-vessel wall interactions, invariably followed by thrombus formation. A low dose of endotoxin markedly increased, while a high dose significantly reduced thrombus formation. The reducing effect of the high dose can be completely offset by indometacin, indicating the involvement of prostaglandin I2.
我们使用一种光电器件证明，内毒素可调节血小板活化因子（PAF）诱导的豚鼠肠系膜动脉血栓形成。事实上，PAF局部灌注可诱导血小板与血管壁相互作用的产生，并总是伴随着血栓形成。低剂量内毒素显著增加血栓形成，而高剂量则显著减少血栓形成。高剂量的这种减少作用可被吲哚美辛完全抵消，表明前列腺素I2参与其中。
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