感染、血管生成、重塑——干细胞是颌骨骨病的答案吗？
Infection, vascularization, remodelling--are stem cells the answers for bone diseases of the jaws?
出版信息
Head Face Med. 2011 Feb 18;7:5. doi: 10.1186/1746-160X-7-5.
Abstract
Osteonecrosis after craniofacial radiation (ORN), osteomyelitis and bisphosphonates related necrosis of the jaw (BRONJ) are the predominant bone diseases in Cranio- and Maxillofacial surgery. Although various hypothesis for the pathophysiological mechanisms including infection, altered vascularisation or remodelling exist, the treatment is still a challenge for clinicians. As the classical pharmacological or surgical treatment protocols have only limited success, stem cells might be a promising treatment option, indicated by recently published data.
摘要
颅颌面放射治疗后骨坏死（ORN）、骨髓炎和双膦酸盐相关颌骨坏死（BRONJ）是颅颌面外科中主要的骨病。尽管存在包括感染、血管改变或重塑等多种病理生理机制的假设，但治疗仍然是临床医生面临的挑战。由于经典的药物治疗或手术治疗方案效果有限，因此最近发表的数据表明，干细胞可能是一种有前途的治疗选择。
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2
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Tissue Eng Part A. 2010 Aug;16(8):2475-83. doi: 10.1089/ten.TEA.2009.0546.
3
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