Head Face Med. 2011 Feb 18;7:5. doi: 10.1186/1746-160X-7-5.
Osteonecrosis after craniofacial radiation (ORN), osteomyelitis and bisphosphonates related necrosis of the jaw (BRONJ) are the predominant bone diseases in Cranio- and Maxillofacial surgery. Although various hypothesis for the pathophysiological mechanisms including infection, altered vascularisation or remodelling exist, the treatment is still a challenge for clinicians. As the classical pharmacological or surgical treatment protocols have only limited success, stem cells might be a promising treatment option, indicated by recently published data.
颅颌面放射治疗后骨坏死（ORN）、骨髓炎和双膦酸盐相关颌骨坏死（BRONJ）是颅颌面外科中主要的骨病。尽管存在包括感染、血管改变或重塑等多种病理生理机制的假设，但治疗仍然是临床医生面临的挑战。由于经典的药物治疗或手术治疗方案效果有限，因此最近发表的数据表明，干细胞可能是一种有前途的治疗选择。
