Department of Radiology, Beijing Chuiyangliu Hospital, Beijing 100022, China.
Eur J Radiol. 2012 Mar;81(3):484-90. doi: 10.1016/j.ejrad.2010.12.069. Epub 2011 Feb 18.
This meta-analysis evaluates the diagnostic accuracy of diffusion-weighted MR imaging with ADC values for differentiation between malignant and benign hepatic focal lesions. From retrieved articles, we selected 7 sets of data in 6 articles, which met all the included criteria, for meta-analysis. The pooled sensitivity and specificity were 86% (95% CI, 0.83-0.90) and 84% (95% CI, 0.78-0.88), respectively. However, notable heterogeneity between studies was noted and no covariate evaluated can explain the cause. Only b factor correlated with the mean ADC values of malignant and benign hepatic tumors. In conclusion, ADC value was useful for differentiation between malignant and benign hepatic focal lesions. But, significant heterogeneity between studies underlines the need for further efforts to optimize standardization and reproducibility of the utilized techniques and methods.
这项荟萃分析评估了扩散加权磁共振成像（DWI）及其 ADC 值在鉴别肝良恶性局灶性病变中的诊断准确性。从检索到的文章中，我们选择了符合所有纳入标准的 6 篇文章中的 7 组数据进行荟萃分析。汇总的敏感性和特异性分别为 86%（95%置信区间，0.83-0.90）和 84%（95%置信区间，0.78-0.88）。然而，研究之间存在显著的异质性，且没有评估出的协变量可以解释其原因。只有 b 值与良恶性肝肿瘤的平均 ADC 值相关。总之，ADC 值有助于鉴别肝良恶性局灶性病变。但是，研究之间存在显著的异质性，这突出表明需要进一步努力优化所使用技术和方法的标准化和可重复性。
