Centre de recherche en rhumatologie et immunologie, CHU de Québec, QC, Canada.
C R Biol. 2011 Feb;334(2):100-17. doi: 10.1016/j.crvi.2010.12.005. Epub 2011 Jan 17.
Nucleosides and nucleotides are now considered as extracellular signalling molecules, like neurotransmitters and hormones. Hepatic cells, amongst other cells, ubiquitously express specific transmembrane receptors that transduce the physiological signals induced by extracellular nucleosides and nucleotides, as well as various cell surface enzymes that regulate the levels of these mediators in the extracellular medium. Here, we cover various aspects of the signalling pathways initiated by extracellular nucleosides and nucleotides in the liver, and discuss their overall impact on hepatic physiology.
核苷和核苷酸现在被认为是细胞外信号分子，类似于神经递质和激素。肝实质细胞和其他细胞普遍表达特定的跨膜受体，这些受体转导细胞外核苷和核苷酸诱导的生理信号，以及各种细胞表面酶，这些酶调节细胞外介质中这些介质的水平。在这里，我们涵盖了细胞外核苷和核苷酸在肝脏中引发的信号通路的各个方面，并讨论了它们对肝脏生理学的总体影响。
