• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

近年来衣原体对宿主细胞骨架和膜运输途径的颠覆作用的研究进展。

Recent advances in Chlamydia subversion of host cytoskeletal and membrane trafficking pathways.

机构信息

Department of Microbiology and Immunology, Cornell College of Veterinary Medicine, Ithaca, NY 14850, USA.

出版信息

Microbes Infect. 2011 Jun;13(6):527-35. doi: 10.1016/j.micinf.2011.02.001. Epub 2011 Feb 18.

DOI:10.1016/j.micinf.2011.02.001
PMID:21334451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3092832/
Abstract

Chlamydia species are obligate intracellular bacteria that cause sexually transmitted disease, ocular infections and atypical pneumonia. This review highlights recent advances describing the mechanisms by which Chlamydia subvert host cytoskeleton and membrane trafficking pathways to create a replication competent niche.

摘要

衣原体属是专性细胞内细菌，可引起性传播疾病、眼部感染和非典型肺炎。本文综述了近年来描述衣原体颠覆宿主细胞骨架和膜运输途径以创建具有复制能力的小生境的机制的进展。

相似文献

1
Recent advances in Chlamydia subversion of host cytoskeletal and membrane trafficking pathways.近年来衣原体对宿主细胞骨架和膜运输途径的颠覆作用的研究进展。
Microbes Infect. 2011 Jun;13(6):527-35. doi: 10.1016/j.micinf.2011.02.001. Epub 2011 Feb 18.
2
Recent insights into the mechanisms of Chlamydia entry.衣原体进入机制的最新见解。
Cell Microbiol. 2005 Dec;7(12):1714-22. doi: 10.1111/j.1462-5822.2005.00627.x.
3
Chlamydia--host cell interactions: recent advances on bacterial entry and intracellular development.衣原体与宿主细胞的相互作用：细菌进入及细胞内发育的最新进展
Traffic. 2004 Aug;5(8):561-70. doi: 10.1111/j.1398-9219.2004.00207.x.
4
Cross Talk between ARF1 and RhoA Coordinates the Formation of Cytoskeletal Scaffolds during Chlamydia Infection.ARF1 和 RhoA 之间的串扰协调衣原体感染期间细胞骨架支架的形成。
mBio. 2021 Dec 21;12(6):e0239721. doi: 10.1128/mBio.02397-21. Epub 2021 Dec 14.
5
Chlamydia trachomatis Subverts Alpha-Actinins To Stabilize Its Inclusion.沙眼衣原体颠覆肌动蛋白以稳定其包含体。
Microbiol Spectr. 2023 Feb 14;11(1):e0261422. doi: 10.1128/spectrum.02614-22. Epub 2023 Jan 18.
6
Manipulation of the Host Cell Cytoskeleton by Chlamydia.衣原体对宿主细胞细胞骨架的操纵。
Curr Top Microbiol Immunol. 2018;412:59-80. doi: 10.1007/82_2016_10.
7
Subversion of Cell-Autonomous Host Defense by Chlamydia Infection.衣原体感染对细胞自主宿主防御的颠覆。
Curr Top Microbiol Immunol. 2018;412:81-106. doi: 10.1007/82_2016_13.
8
Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry.衣原体利用丝状伪足捕获和类似巨胞饮的途径进入宿主细胞。
PLoS Pathog. 2018 May 4;14(5):e1007051. doi: 10.1371/journal.ppat.1007051. eCollection 2018 May.
9
Pathogens and polymers: microbe-host interactions illuminate the cytoskeleton.病原体与聚合物：微生物-宿主相互作用阐明细胞骨架。
J Cell Biol. 2011 Oct 3;195(1):7-17. doi: 10.1083/jcb.201103148.
10
Lipid acquisition by intracellular Chlamydiae.细胞内衣原体的脂质获取。
Cell Microbiol. 2012 Jul;14(7):1010-8. doi: 10.1111/j.1462-5822.2012.01794.x. Epub 2012 Apr 17.

引用本文的文献

1
COPB1-knockdown induced type I interferon signaling activation inhibits intracellular proliferation.COPB1基因敲低诱导的I型干扰素信号激活抑制细胞内增殖。
Front Microbiol. 2025 Mar 6;16:1566239. doi: 10.3389/fmicb.2025.1566239. eCollection 2025.
2
Chlamydia trachomatis Alters Mitochondrial Protein Composition and Secretes Effector Proteins That Target Mitochondria.沙眼衣原体改变线粒体蛋白组成并分泌靶向线粒体的效应蛋白。
mSphere. 2022 Dec 21;7(6):e0042322. doi: 10.1128/msphere.00423-22. Epub 2022 Oct 26.
3
Lipid larceny: channelizing host lipids for establishing successful pathogenesis by bacteria.脂类掠夺：细菌为建立成功的发病机制而对宿主脂类的利用。
Virulence. 2021 Dec;12(1):195-216. doi: 10.1080/21505594.2020.1869441.
4
Taking control: reorganization of the host cytoskeleton by .掌控：由……对宿主细胞骨架进行的重组
F1000Res. 2017 Nov 29;6:2058. doi: 10.12688/f1000research.12316.1. eCollection 2017.
5
Bacterial Metabolism Shapes the Host-Pathogen Interface.细菌代谢塑造宿主-病原体界面。
Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.VMBF-0027-2015.
6
The Type III Secretion System-Related CPn0809 from Chlamydia pneumoniae.肺炎衣原体中与III型分泌系统相关的CPn0809
PLoS One. 2016 Feb 19;11(2):e0148509. doi: 10.1371/journal.pone.0148509. eCollection 2016.
7
Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors.沙眼衣原体从体内到体外的转变揭示了相变和毒力因子下调的机制。
PLoS One. 2015 Jul 24;10(7):e0133420. doi: 10.1371/journal.pone.0133420. eCollection 2015.
8
Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections.作为病原体靶点的Rho GTP酶：聚焦可治愈的性传播感染
Small GTPases. 2015;6(2):108-18. doi: 10.4161/21541248.2014.991233. Epub 2015 May 29.
9
The intracellular bacteria Chlamydia hijack peroxisomes and utilize their enzymatic capacity to produce bacteria-specific phospholipids.细胞内细菌衣原体劫持过氧化物酶体，并利用其酶促能力来产生细菌特异性磷脂。
PLoS One. 2014 Jan 23;9(1):e86196. doi: 10.1371/journal.pone.0086196. eCollection 2014.
10
Intracellular survival and persistence of Chlamydia muridarum is determined by macrophage polarization.鼠衣原体在巨噬细胞内的生存和持续存在取决于巨噬细胞的极化。
PLoS One. 2013 Aug 14;8(8):e69421. doi: 10.1371/journal.pone.0069421. eCollection 2013.

本文引用的文献

1
A Functional Slow Recycling Pathway of Transferrin is Required for Growth of Chlamydia.沙眼衣原体生长需要转铁蛋白的功能性缓慢循环途径。
Front Microbiol. 2010 Oct 8;1:112. doi: 10.3389/fmicb.2010.00112. eCollection 2010.
2
Chlamydia trachomatis intercepts Golgi-derived sphingolipids through a Rab14-mediated transport required for bacterial development and replication.沙眼衣原体通过 Rab14 介导的运输拦截高尔基体衍生的鞘脂，这一运输对于细菌的发育和复制是必需的。
PLoS One. 2010 Nov 22;5(11):e14084. doi: 10.1371/journal.pone.0014084.
3
Uncivil engineers: Chlamydia, Salmonella and Shigella alter cytoskeleton architecture to invade epithelial cells.不文明工程师：衣原体、沙门氏菌和志贺氏菌改变细胞骨架结构以入侵上皮细胞。
Future Microbiol. 2010 Aug;5(8):1219-32. doi: 10.2217/fmb.10.77.
4
The conserved Tarp actin binding domain is important for chlamydial invasion.保守的 Tarp 肌动蛋白结合结构域对衣原体入侵很重要。
PLoS Pathog. 2010 Jul 15;6(7):e1000997. doi: 10.1371/journal.ppat.1000997.
5
Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.Tarp 通过与人类衔接蛋白 SHC1 相互作用调节早期沙眼衣原体诱导的宿主细胞存活。
J Cell Biol. 2010 Jul 12;190(1):143-57. doi: 10.1083/jcb.200909095.
6
cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis.胞质型磷脂酶A2调节I型干扰素的表达及对沙眼衣原体的细胞内免疫。
J Biol Chem. 2010 Jul 9;285(28):21625-35. doi: 10.1074/jbc.M110.103010. Epub 2010 May 7.
7
Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac.沙眼衣原体血清型 D 诱导的肌动蛋白重组——效应蛋白 CT166 靶向 Rac 的关键作用证据。
PLoS One. 2010 Mar 25;5(3):e9887. doi: 10.1371/journal.pone.0009887.
8
Specific chlamydial inclusion membrane proteins associate with active Src family kinases in microdomains that interact with the host microtubule network.特定的衣原体包涵体膜蛋白与小窝内的活性Src 家族激酶相关，这些激酶与宿主微管网络相互作用。
Cell Microbiol. 2010 Sep 1;12(9):1235-49. doi: 10.1111/j.1462-5822.2010.01465.x. Epub 2010 Mar 19.
9
A loss-of-function screen reveals Ras- and Raf-independent MEK-ERK signaling during Chlamydia trachomatis infection.一项功能丧失筛选实验揭示了沙眼衣原体感染过程中 Ras 和 Raf 非依赖性 MEK-ERK 信号转导。
Sci Signal. 2010 Mar 16;3(113):ra21. doi: 10.1126/scisignal.2000651.
10
Multiple host proteins that function in phosphatidylinositol-4-phosphate metabolism are recruited to the chlamydial inclusion.多种参与磷脂酰肌醇-4-磷酸代谢的宿主蛋白被招募到衣原体包涵体中。
Infect Immun. 2010 May;78(5):1990-2007. doi: 10.1128/IAI.01340-09. Epub 2010 Mar 15.