体育锻炼对哮喘儿童肺损伤和氧化应激的影响。

Effects of physical exercise on lung injury and oxidant stress in children with asthma.

作者信息

Gunay Ozlem, Onur Ece, Yilmaz Ozge, Dundar Pinar E, Tikiz Canan, Var Ahmet, Yuksel Hasan

机构信息

Celal Bayar University Medical Faculty, Dept of Biochemistry, Manisa, Turkey.

出版信息

Allergol Immunopathol (Madr). 2012 Jan-Feb;40(1):20-4. doi: 10.1016/j.aller.2010.10.006. Epub 2011 Feb 19.

DOI:10.1016/j.aller.2010.10.006

PMID:21334801

Abstract

BACKGROUND

The aim of this study was to investigate the influence of exercise training on oxidative stress and markers of lung inflammation in children with asthma.

METHODS

Thirty children aged 8-13 years diagnosed with asthma were enrolled in the study as well as 13 healthy children. One group received only pharmacological treatment and the other group was also enrolled in an exercise programme. Venous blood and 24-hour urine samples were obtained from the children enrolled in the study at the beginning and end of the study. Leukotriene E4 and creatinine levels were measured in the urine and matrix metallopeptidase (MMP-9), endothelin-1(ET-1), malnodialdehyde (MDA), IgE and specific IgE levels were measured in blood samples.

RESULTS

Leukotriene E4, MDA and MMP9 levels decreased significantly with treatment in both groups (p < 0.001). However, ET-1 levels decreased significant only in the exercise group (26.5 ± 3.6 vs 21.3 ± 2.4 pg/ml respectively, p = 0.001). Moreover, ET-1 levels were found to be significantly lower in the exercise group compared to the only pharmacotherapy group (24.2 ± 3.1 vs 21.3 ± 2.4 pg/ml, p=0.007).

CONCLUSIONS

Positive influences of exercise training in children with asthma may be mediated by decrease in ET-1 levels.

摘要

背景

本研究旨在调查运动训练对哮喘儿童氧化应激和肺部炎症标志物的影响。

方法

30名年龄在8至13岁被诊断为哮喘的儿童以及13名健康儿童参与了本研究。一组仅接受药物治疗，另一组还参加了运动项目。在研究开始和结束时，从参与研究的儿童中采集静脉血和24小时尿液样本。测量尿液中的白三烯E4和肌酐水平，以及血液样本中的基质金属蛋白酶（MMP-9）、内皮素-1（ET-1）、丙二醛（MDA）、免疫球蛋白E（IgE）和特异性IgE水平。

结果

两组治疗后白三烯E4、MDA和MMP9水平均显著降低（p < 0.001）。然而，ET-1水平仅在运动组显著降低（分别为26.5 ± 3.6与21.3 ± 2.4 pg/ml，p = 0.001）。此外，发现运动组的ET-1水平显著低于仅接受药物治疗的组（24.2 ± 3.1与21.3 ± 2.4 pg/ml，p = 0.007）。