Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Surg Oncol. 2012 Jun;21(2):125-31. doi: 10.1016/j.suronc.2011.01.001. Epub 2011 Feb 19.
Survivin a multifunctional protein that controls cell division, inhibition of apoptosis and promotion of angiogenesis. It is expressed in most human neoplasm, but is absent in normal and differentiated tissues. The purpose of this article is to overview the expression of survivin, effect of its expression in response to treatment, correlation with other markers and newer advancement in targeting survivin.
A detailed search of Medline was carried out using the following search strategy: "((survivin) OR ((apoptosis) AND (inhibitor OR inhibitors))) AND ((breast) AND (neoplasm OR neoplasms OR tumor OR tumor OR cancer OR carcinoma))". Abstract of all articles thus identified were reviewed to identify the relevant studies, full articles of studies thus identified were then obtained and reviewed. All relevant data was extracted and tabulated.
Survivin expression by Immunohistochemistry was identified in 65.3% (55.2-90.0%) of the breast cancer patients among the identified studies while survivin mRNA by RT-PCR was identified in 93.6% (90-97%). Survivin expression has been reported to be associated with over expression of HER 2, vascular endothelial growth factor (VEGF), urokinase plasminogen activator (uPA)/PAI-1.
Survivin is over expressed in majority of breast cancers. The over expression of survivin is found to correlate with HER 2 and EGFR expression. Survivin expression has been found to confer resistance to chemotherapy and radiation. Targeting survivin in experimental models improves survival. More studies are needed on the role of survivin in multi drug resistance (MDR) in the presence of Pgp/uPA/PAI-1 and the impact of survivin over expression in triple negative breast cancer.
Survivin 是一种多功能蛋白，可控制细胞分裂、抑制细胞凋亡和促进血管生成。它在大多数人类肿瘤中表达，但在正常和分化组织中不存在。本文旨在概述 survivin 的表达，其表达对治疗的反应，与其他标志物的相关性以及针对 survivin 的最新进展。
使用以下搜索策略在 Medline 上进行了详细搜索：“((survivin) OR ((apoptosis) AND (inhibitor OR inhibitors))) AND ((breast) AND (neoplasm OR neoplasms OR tumor OR tumor OR cancer OR carcinoma))”。 对所有鉴定出的文章的摘要进行了审查，以确定相关的研究，然后获得并审查了鉴定出的研究的全文。提取并制表所有相关数据。
在确定的研究中，免疫组化鉴定出 65.3%（55.2-90.0%）的乳腺癌患者存在 survivin 表达，而 RT-PCR 鉴定出 93.6%（90-97%）的 survivin mRNA。 survivin 表达已被报道与 HER 2、血管内皮生长因子 (VEGF)、尿激酶型纤溶酶原激活物 (uPA)/PAI-1 的过度表达相关。
大多数乳腺癌中存在 survivin 的过度表达。survivin 的过度表达被发现与 HER 2 和 EGFR 表达相关。 survivin 表达已被发现可导致对化疗和放疗的耐药性。在 Pgp/uPA/PAI-1 存在的情况下，实验模型中靶向 survivin 可提高存活率。需要进一步研究 survivin 在多药耐药 (MDR) 中的作用，以及 survivin 过度表达在三阴性乳腺癌中的影响。
