Wang Ruirui, Li Xiaoying, Gan Yu, Liao Jinzhuang, Han Shuangze, Li Wei, Deng Gaoyan
Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
J Cancer. 2024 Jan 20;15(5):1366-1377. doi: 10.7150/jca.89831. eCollection 2024.
Human malignancies exhibit elevated levels of survivin, and have been linked to poor prognosis. Targeting survivin expression is a promising therapeutic strategy against cancer cells. Natural compounds have become a hot topic in research due to their non-toxic, non-invasive, and efficient treatment of multiple diseases. In this current investigation, it was discovered that Dioscin, as a natural compound, exerted profound antitumor activity against NSCLC cell lines, inhibiting NSCLC cell viability and promoting apoptosis. Further mechanistic studies showed that Dioscin promoted ubiquitination-mediated survivin degradation via strengthening the interaction between survivin and the E3 ubiquitin ligase Fbxl7. Furthermore, Dioscin exhibited a strong tumor suppressive effect in xenograft tumor models, and Dioscin treatment led to a notable decrease in tumor volume and weight. Based on our findings, Dioscin is expected to be a potential antitumor agent for non-small cell lung cancer treatment.
人类恶性肿瘤中survivin水平升高，且与预后不良有关。靶向survivin表达是一种很有前景的抗癌细胞治疗策略。天然化合物因其无毒、无创且能有效治疗多种疾病而成为研究热点。在本次研究中，发现薯蓣皂苷作为一种天然化合物，对非小细胞肺癌细胞系具有显著的抗肿瘤活性，可抑制非小细胞肺癌细胞活力并促进细胞凋亡。进一步的机制研究表明，薯蓣皂苷通过加强survivin与E3泛素连接酶Fbxl7之间的相互作用，促进泛素化介导的survivin降解。此外，薯蓣皂苷在异种移植肿瘤模型中表现出强大的肿瘤抑制作用，薯蓣皂苷治疗导致肿瘤体积和重量显著降低。基于我们的研究结果，薯蓣皂苷有望成为治疗非小细胞肺癌的潜在抗肿瘤药物。
